Dong-Ho Ha, Presenter: Nothing to Disclose

Hwan Tae Park, Abstract Co-Author: Nothing to Disclose

Sunseob Choi MD, PhD, Abstract Co-Author: Nothing to Disclose

To simultaneously evaluate the sequential alteration of the DTI indices, T2 values and subjective visual signal intensity change on various fat suppression techniques in the early state of denervated skeletal muscle in the rat model.

 Institutional animal use and care committee approval was obtained. Complete neurotmesis of the sciatic nerve of 8 white rats was performed. We examined MR studies of the normal muscle and follow-up studies at 3 days, 1 week, and 2 weeks after surgery. FA, mADC and T2 values ware measured at the calf muscles. We also subjectively graded visual signal intensity change on CHESS, STIR and IDEAL imaging. Statistical significances were obtained.

 FA values at 3 days (0.35±0.06, P=0.012), 1 week (0.29±0.04, P=0.017), 2 weeks (0.34±0.05, P=0.017) were significantly lower than that in control group (0.54±0.17). The mADC of the all follow up periods decreased, but statistically insignificant. T2 values began to increase at three days without statistical significance (34.08±1.42, P=0.069), significantly increased at 2 weeks (38.11±6.41, P=0.017) and marked increased at 2 weeks (46.53±5.17, P=0.012), compared with control group (32.71±1.33). Visual signal intensity changes were variously at 1 week and more prominent at 2 weeks. Grading the lesions was identical in all cases.

FA and T2 values will be effective parameters to observe the early state of denervated skeletal muscle.

 The calculation of FA and T2 value wiil be effective noninvasive methods for the evaluation of acute skeletal deneravated muscle, even though it has various limitations. Fat suppression techniques did not affect the early detection of high signal abnormality on T2 weighted image and grading of lesion.  

Ha, D, Park, H, Choi, S, Diffusion Tensor Imaging, T2 Mapping, and Various Fat Suppression Imaging in Early State of Denervated Skeletal Muscle: Experimental Study in Rats.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14045620.html