Jin Ah Kim MD, Presenter: Nothing to Disclose

Jon D. Blumenfeld JD, Abstract Co-Author: Nothing to Disclose

Silvina Paola Dutruel MD, Abstract Co-Author: Nothing to Disclose

Nanda Deepa Thimmappa MD, MBBS, Abstract Co-Author: Nothing to Disclose

Warren O. Bobb, Abstract Co-Author: Nothing to Disclose

Stephanie Donahue, Abstract Co-Author: Nothing to Disclose

Martin R. Prince MD, PhD, Abstract Co-Author: Patent agreement, General Electric Company Patent agreement, Hitachi, Ltd Patent agreement, Siemens AG Patent agreement, Toshiba Corporation Patent agreement, Koninklijke Philips NV Patent agreement, Nemoto Kyorindo Co, Ltd Patent agreement, Bayer AG Speaker Honorarium, Bayer AG Patent agreement, Lantheus Medical Imaging, Inc Patent agreement, Bracco Group Speaker Honorarium, Bracco Group Patent agreement, Covidien AG Patent agreement, Topspins, Inc Stockholder, Topspins, Inc

To evaluate the prevalence and natural history of pancreatic cysts in ADPKD subject 

ADPKD patients enrolled in the Rogosin Institute ADPKD Data Repository (n=178; male 46%), who underwent MRI scans between November, 2006 and November, 2013 (age 18 to 84 years; mean = 47.5 years) were evaluated for pancreatic cysts on axial and coronal single-shot fast spin-echo (SSFSE) images obtained at 1.5T (TE=183.0, matrix = 256 x 256 or 512 x 256 [high resolution], slice thickness =8.0). Pancreatic cyst diameters were measured with electronic calipers; cysts measuring >2 mm were counted. Estimated GFR (eGFR), using 4-variable MDRD formula, was determined at baseline MRI (range 5-155 ml/min/1.73m2)..The control group included 71 patients without ADPKD or pancreatic disease who were matched for age, sex, race, GFR, and date of MRI. Changes in cyst number and size were recorded for 28 subjects with > 1 scans separated by more than 1 year.

At least one pancreatic cyst was found in 61 (34%) ADPKD patients (male 44%, eGFR 65-121 ml/min/1.73m2). One pancreatic cyst, more than one cyst, and more than 10 cysts were found in 41%, 54%, and 5% patients, respectively. Cyst size ranged from 2 mm to 57 mm (median = 4 mm). Of the 28 ADPKD patients with follow-up MRI, 39% showed changes during the follow-up period: cyst number increased in 17.9%, cyst size increased in 32.1%. Of 71 ADPKD cases with a matched control, 31% had pancreatic cysts compared to 17(24%) in the control population (p=0.11).

Prevalence of pancreatic cysts was similar in the ADPKD and non-ADPKD control population. However, the reported prevalence of pancreatic cysts was lower by SSFSE than previously reported by thin slice 3D MRCP 44.7%. Changes in pancreatic cyst number and size occur commonly in ADPKD. The clinical significance of these changes has not been established.

Although pancreatic cysts have been observed in ADPKD, their prevalence and natural history have not been established especially using MRI, which is modality of choice in detecting pancreatic cysts as well as evaluating ADPKD.

Kim, J, Blumenfeld, J, Dutruel, S, Thimmappa, N, Bobb, W, Donahue, S, Prince, M, The Prevalence and the Natural Course of Pancreatic Cysts in ADPKD.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14045527.html