Bo Jiang MD, PhD, Presenter: Nothing to Disclose

Jiaying Gong, Abstract Co-Author: Nothing to Disclose

Ximin Pan, Abstract Co-Author: Nothing to Disclose

Meiyu Hu, Abstract Co-Author: Nothing to Disclose

PING XU, Abstract Co-Author: Nothing to Disclose

To assess hand and foot motor cortex mapping features in patients with brain tumors adjacent to central sulcus by using BOLD-fMRI technique.

Twenty patients with brain tumors near central sulcus were obtained fMRI in 1.5 T superconduct by performing fingers-thumb tapping (FTT) and toes extension-flexion (TEF), which divided into group 1 (n=12) with impaired and group 2 (n=8) with normal limb muscle strength. Tumor-side activation degree was quantified by activated cortex volume, and graded as hypointense, intense, isointense when compared with that in healthy side. The activation degree and activation shift were compared between 2 groups and between 2 tasks (α=0.05).

1. Primary sensorimotor (SM1) activation was detected in 20 patients in FTT task. Activation distribution differed statistically between group 1 (11 hypointense, 0 intense, 1 isointense) and group 2 (2 hypointense, 1 intense, 5 isointense) (X2=9.48, P<0.01). Incidence of hypointense activation was different between 2 groups (X2=9.38, P<0.005). Activation shift occurred in 10 patients in group 1 and in 4 in group 2, frequency of which differed between hypointense and none- hypointense (X2=8.80, P<0.005), but not between 2 groups (X2=1.20, P>0.25). 2. Paracentral lobule (PCL) activation was evoked in 17 patients in TEF task. No statistical difference of activation distribution existed between group 1 (8 hypointense, 1 intense, 0 isointense) and group 2 (5 hypointense, 1 intense, 2 isointense) (X2=7.46, P>0.05). No difference of hypointense activation incidence was noted in 2 groups (X2=0.037, P>0.75). Activation shift occurred in 5 in group 1 and in 2 in group 2, frequency of which showed no difference between hypointense and none-hypointense (X2=2.03, P>0.1), or between 2 groups (X2=0.615, P>0.25). 3. No difference of hypointense incidence was found between SM1 and PCL (X2=0.16, P>0.5), nor frequency of activation shift between SM1 and PCL in the 20 patients (X2=2.05, P>0.1).  

BOLD-fMRI reveals activation pattern alterations of hand and foot motor cortex induced by the tumor near central sulcus. SM1 and PCL activation shifts imply actively protective responses to tumoral invasion. PCL seems more flexible in configuration than SM1.

Hand and foot motor cortex mapping demonstrated by fMRI provides a guideline to pre-surgical protocol planning for the patients with tumors close to central sulcus.

Jiang, B, Gong, J, Pan, X, Hu, M, XU, P, Hand and Foot Motor Cortex Activation fMRI Assessment in Patients with Brain Tumors Adjacent to Central Sulcus.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14045510.html