Sung Shine Shim, Presenter: Nothing to Disclose

Sean B. Fain PhD, Abstract Co-Author: Research Grant, General Electric Company Research Consultant, Marvel Medtech, LLC

Ronald L. Sorkness, Abstract Co-Author: Nothing to Disclose

Nizar Jarjour, Abstract Co-Author: Nothing to Disclose

Loren Denlinger MD, Abstract Co-Author: Nothing to Disclose

Mark L. Schiebler MD, Abstract Co-Author: Shareholder, Cellectar Biosciences, Inc

The aim of this study was to assess airway luminal change found on post processing of  HRCT images  in asthma patients and to determine if there was any correlation with their respective clinical indices and BMI.

We prospectively enrolled a total of 152 severe asthma research program (SARP) subjects. The airway deltalumen was defined as the ratio of difference between airway lumen area found at HRCT during total lung capacity (TLC) and functional residual capacity (FRC) / airway lumen area at TLC. Deltalumen of all 1st -6th generation airways was measured using VIDATM software, and the mean values for each subject were calculated. Correlations were made between mean value of deltalumen and age, sex, duration of asthma, severity, spirometry parameters including baseline FEV1 percentage predicted (PP), baseline FEF 25-75% PP, and body mass index (BMI). SPSS package was used to test for any statistical significance for each of the variables measured in the asthmatics  (Spearman rank correlation coefficient and multivariate regression).  

We found that deltalumen showed the positive correlation with BMI (r=0.274, p=0.001), baseline FEV1 pp.(r=0.163, p=0.045) and FEF 25-75 pp. (r=0.182, p=0.028) and multivariate regression analysis of deltalumen in asthmatics was independently determined by BMI (P<0.001).    By gender, BMI in females was also found to be positively correlated with deltalumen (r=0.391, p<0.001) but, this was not found for male subejcts (r=0.023, p=0.860).   This association was also different in non-severe and severe asthma groups. BMI was found to be significantly correlated with deltalumen for the non-severe asthmatics (r= 0.417, p=0.001), but not for  severe asthmatics (r=0.180, p=0.095).

Deltalumen was found to be positively associated with lung function and BMI. BMI was most highly correlated with deltalumen in the female non-severe asthmatic group.    

Weight control in female non-severe asthmatics may prove to be important for their lung function. As this group gains weight they are more likely to have collapse of their airways.

Shim, S, Fain, S, Sorkness, R, Jarjour, N, Denlinger, L, Schiebler, M, Female Asthmatics Show a BMI Dependent Change in their Deltalumen: SARP Cohort Data Shows that Females are More at Risk than Males for Bronchial Collapse with an Increase in Weight.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14045501.html