E-Ryung Choi MD, Presenter: Nothing to Disclose

Byung Kwan Park MD, Abstract Co-Author: Nothing to Disclose

Jung Jae Park MD, Abstract Co-Author: Nothing to Disclose

Tumor volume is a significant prognostic factor of cervical cancer. It is still unknown about outcome of biopsy-proven FIGO stage IB1 cervical cancer which is invisible on preoperative magnetic resonance imaging (MRI). The aim was to retrospectively evaluate the postoperative outcomes of MR-invisible IB1 cervical cancers.

Between January 2001 and December 2007, we reviewed the medical records of 86 patients with biopsy-proven FIGO stage IB1 cervical cancer which was invisible on MRI. During the same period, we also reviewed the medical records of 260 patients with biopsy-proven FIGO stage IB1 cervical cancer which was visible on MRI. Both of these cancer groups were treated with radical hysterectomy and lymph node dissection. MR-invisible and MR-visible IB1 cancers were compared in terms of pathologic parameters and long-term survival rate.

The median sizes and depths of stromal invasion of MR-invisible versus MR-visible IB1 cancers were 4.5±7.1 mm and 33.3±20.1% versus 30±14 mm and 66.7±26.6%, respectively (p=0.000). The incidences of lymph node metastasis, parametrial invasion, and lymphovascular invasion were 1.1% (1/86) and 18.8% (49/260) (p=0.000, odd ratio=19.7), 0% (0/86) and 6.5% (17/260) (p=0.009, odd ratio=12.4), and 4.7% (4/86) and 26.9% (70/260) (p=0.000, odd ratio=7.6) in the MR-invisible and MR-visible IB1 cancers, respectively. Recurrence-free and overall 5-year survival rates of MR-invisible versus MR-visible IB1 cancers were 98.8% (85/86) versus 91.2% (237/260) and 100% (86/86) versus 95.8% (249/260), respectively (p=0.011 and 0.045).

MR-invisible IB1 cancer provides better postoperative outcomes than MR-visible Ib1 cancer because of the much lower tumor burden.

MR-invisible FIGO stage IB1 cervical cancer accounting for 25% of IB1 cancers might be treated less invasively because of lower tumor burden than MR-visible FIGO stage IB1 cervical cancer.

Choi, E, Park, B, Park, J, Postoperative Outcomes of MR-invisible FIGO Stage IB1 Cervical Cancer.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14045494.html