Catherine Roy MD, Presenter: Nothing to Disclose

Mickael Ohana MD, MSc, Abstract Co-Author: Nothing to Disclose

Philippe Host MD, Abstract Co-Author: Nothing to Disclose

Guillaume Alemann MD, MS, Abstract Co-Author: Nothing to Disclose

amina jeledi MD, Abstract Co-Author: Nothing to Disclose

To determine the normal values of renal cortex and parenchyma perfusion parameters using a 320-detector MDCT including the entire kidney

54 normal renal function patients underwent a renal perfusion imaging using a 320-slice dynamic volume CT unit (Aquilion One, Toshiba Medical Systems, Ottawara, Japan) including the whole organ without table movement. The dynamic CT protocol included 24 volumes with a total acquisition time until 90sec, a rotation time of 0.5sec, 0.5ml/kg of a highly concentrated contrast medium (Iomeprol 400 mg iodine/ml) with a flow rate of 5-6ml/sec pushed by 50 ml of saline serum. Perfusion parameters were calculated using the maximum slope and Patlak model from the dedicated software of our CT unit after a non-rigid motion correction. Mean blood flow (AF), blood volume (BV) and clearance (Cl) were recorded by mean of ROI located and included all the parenchyma and all the cortex. Measurements were performed in the three orthogonal plans. The resulting quantitative voxel values were transformed into 3D color maps for visual inspection and analysis. Whole kidney perfusion parameters were calculated after registration of the volume of each kidney. Radiation dose was recorded.

Imaging quality was satisfactory for a morphologic assessment. Radiation dose was between 7-10mSv (mean 8.3). Our results were for AF: 202+24, 315+29 ml/100g/min; BV: 42+18, 75+18 ml/100g and Cl: 47+26, 38 + 12 ml/100g/min for whole parenchyma and cortex, respectively. By calculating the volume of each kidney, we obtained 229+45ml/min, 64+18 ml and 87+28ml/min for AF, BV and Cl, respectively. There was no significant difference of values between right or left kidney. The time for operator processing to record the data was between 2 to 3 min after the non-rigid automatic motion correction process which was taken approximately 10min. There was no impact on the working flow. CT perfusion parameters did not differ by using axial, sagittal or coronal or oblique plans.  

320-Detector MDCT makes it possible to conduct perfusion measurements of the whole kidney without table displacement. Our preliminary results suggest that it is feasible in clinical practice without time consuming and a reasonable radiation dose.

Contrast-enhanced dynamic MDCT of renal perfusion can be easily performed in a routine application, with a reasonable time for post processing and radiation dose.

Roy, C, Ohana, M, Host, P, Alemann, G, jeledi, a, Feasibility of Computed Tomography Perfusion Imaging of the Kidney Using a 320-detector MDCT Unit: Establishment of Normal Perfusion Parameters Values.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14045467.html