Akio Hiwatashi MD, Presenter: Nothing to Disclose

Osamu Togao MD, PhD, Abstract Co-Author: Nothing to Disclose

Koji Yamashita MD, PhD, Abstract Co-Author: Nothing to Disclose

Kazufumi Kikuchi MD, Abstract Co-Author: Nothing to Disclose

Makoto Obara, Abstract Co-Author: Employee, Koninklijke Philips NV

Takashi Yoshiura MD, PhD, Abstract Co-Author: Nothing to Disclose

Hiroshi Honda MD, Abstract Co-Author: Nothing to Disclose

Compared to echo planar (EP) diffusion-weighted imaging (DWI), three-dimensional (3D) turbo field echo with diffusion-sensitized driven-equilibrium (DSDE-TFE) preparation DWI obtains images with higher spatial resolution and less susceptibility artifacts. The purpose of this study was to evaluate feasibility of DSDE-TFE to visualize retinoblastomas compared to EP imaging.

This retrospective study was approved by our institutional review boards, and written informed consent was waived. Eight patients with retinoblastomas (five boys and three girls; age range 0–87 month old; median 21 month) were studied. For DSDE-TFE, motion probing gradients (MPGs) were conducted at one direction with b-values of 0 and 500 s/mm2. The other imaging parameters were as follows: TR/TE = 6.2/3.0 ms, FA = 10°, ETL = 75, FOV = 240 mm, voxel size = 1.5×1.5×1.5 mm3, NEX = 2, and acquisition time = 5 min 22 s. For EP imaging, MPGs were conducted at three directions with b-values of 0 and 1000 s/mm2. The other imaging parameters were as follows: TR/TE = 3000/57 ms, SENSE factor = 2.5, FOV = 230 mm, matrix = 160×128, slice thickness/gap = 3/0 mm, voxel size = 1.4×1.8×3 mm3, NSA = 2, and acquisition time = 2 min 12 s. The apparent diffusion coefficients (ADCs) of each lesion were measured. Statistical analyses were performed with Pearson R and linear regression analysis.

Intraocular lesions were clearly visualized on the DSDE-TFE without obvious geometrical distortion, whereas all showed deformity on EP images. On the DSDE-TFE, the ADCs of the lesions ranged from 0.83×10−3 mm2/s to 2.93×10−3 mm2/s (mean ± SD; 1.73±0.73×10−3 mm2/s). On the EP images, the ADCs ranged from 0.53×10−3 mm2/s to 2.03×10−3 mm2/s (0.93±0.53×10−3 mm2/s). There was a significant correlation in ADC measurement between the DSDE-TFE and EP imaging (r = 0.81, p < 0.05).

With its insensitivity to field inhomogeneity and high spatial resolution, the 3D DSDE-TFE technique enabled us to assess diffusivity in retinoblastomas.

Using DSDE-TFE technique, it was possible to evaluate diffusivity in retinoblastoma with high resolution and less susceptibility artifacts compared to echo planar diffusion-weighted imaging.

Hiwatashi, A, Togao, O, Yamashita, K, Kikuchi, K, Obara, M, Yoshiura, T, Honda, H, Diffusivity of Retinoblastoma: 3D Turbo Field Echo with Diffusion-Sensitized Driven-Equilibrium Preparation Technique (DSDE-TFE) Compared to Echo Planar Imaging.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14045445.html