Purpose/Objective(s):To evaluate the outcome of adjuvant radiotherapy (RT) in FIGO IB-IIA uterine cervical cancer.Materials/Methods:We retrospectively reviewed the medical records of 197 patients with FIGO IB-IIA uterine cervical cancer who had undergone curative surgery followed by adjuvant RT in Yonsei Cancer Center between June 1997 and December 2011. The patient’s median age was 48 years (range, 28-80yrs). Pelvic lymph node dissection and para-aortic lymphnode dissection were performed in 138 (70.1%) and 92 (46.7%) patients, respectively. Adjuvant radiotherapy was delivered to whole pelvis field or extended field with or without brachytherapy up to total dose 50.4 Gy (range, 30-80.4 Gy). Eighty-eight patients were high risk group and 109 patients were low-intermediate risk group. Of whole patients, 71 patients (36%) received adjuvant chemotherapy concurrently or sequentially. Results:The median follow-up period was 54.5 months. Loco-regional recurrence alone was occurred in 6 patients, distant metastasis was in 15 patients, and simultaneous regional and distant metastasis was in 2 patients. For all patients, 5 year locoregional recurrence free survival (LRFS) and 5 year distant metastasis free survival (DMFS) were 95.8% and 89.3%, respectively. Tumor size and non-squamous histology were the significant prognostic factors associated with LRFS (p=0.049) and DMFS (p=0.047), respectively in multivariate analysis.Conclusions: Our results indicate that high loco-regional control rate was achieved by adjuvant RT for early cervical cancer. But, new systemic treatment is needed to be considered to reduce distant metastasis.
Kim, H,
Clinical Outcome of Adjuvant Radiation Therapy in Early Stage Uterine Cervical Cancer. Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL.
http://archive.rsna.org/2014/14043110.html
