Seungbo Lee, Presenter: Nothing to Disclose

Eun-Suk Cho, Abstract Co-Author: Nothing to Disclose

Dahye Lee, Abstract Co-Author: Nothing to Disclose

Jeong-Sik Yu MD, Abstract Co-Author: Nothing to Disclose

Joo Hee Kim, Abstract Co-Author: Nothing to Disclose

Jae-Joon Chung MD, Abstract Co-Author: Nothing to Disclose

10-min delayed hepatocyte phase imaging (HPI) provided satisfactory information for detection of focal hepatic lesion (FHL) in Gd-EOB-DTPA-enhanced liver MRI. However, lesion-to-liver contrast-to-noise ratio (CNR) was significantly lower than 20-min delayed HPI. Increasing the flip angle (FA) from 10° to 30° in HPI improves lesion-to-liver CNR since the higher FA increases T1-weighting. The purpose of the study was to compare the lesion-to-liver CNR and FHL detection sensitivity between 10-min delayed HPI with a 30° FA (10min-FA30) and 20-min delayed HPI with a 10° FA (20min-FA10) in patients with liver metastases. In addition, to determine whether 10min-FA30 could replace 20min-FA10, thus saving time of 10 minutes in acquiring HPI.  

51 patients with 197 liver metastases underwent Gd-EOB-DTPA-enhanced MRI with 10min-FA30 and 20min-FA10 using 3D T1-weighted gradient echo sequence. Lesion-to-liver CNRs on both two HPI sets were calculated. Two radiologists assessed independently the presence of FHLs using a four-point scale. The values were compared with paired t-test and Wilcoxon signed-rank test.

The mean CNR for metastases on 10min-FA30 (268.5 ± 91.9) was significantly higher than that of 20min-FA10 (202.1 ± 71.3). There was no significant difference on detection sensitivity for liver metastases between the two HPI sets for both readers (98.1% sensitivity at 10min-FA30 and 97.8% at 20min-FA10).

10min-FA30 in Gd-EOB-DTPA-enhanced MRI had higher lesion-to-liver CNR with no difference in lesion detection sensitivity, compared to the 20min-FA10. This result indicates that 10min-FA30 could replace 20min-FA10 with a better diagnostic performance for detection of liver metastases and also allows 10 minutes of time-saving.

Using a 30° flip angle, 10-min delayed hepatocyte phase imaging in gadoxetic acid-enhanced MRI can replace 20-min delayed imaging with 10° flip angle with a better diagnostic performance for detection of liver metastases and also allows 10 min of time-saving.

Lee, S, Cho, E, Lee, D, Yu, J, Kim, J, Chung, J, Feasibility of 10-min Delayed MR Imaging with 30° Flip Angle in Gd-EOB-DTPA-enhanced MR Imaging for the Detection of Liver Metastases, Compared with 20-min Delayed MR Imaging with Standard 10° Flip Angle.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14019510.html