Ali Malik MD, Presenter: Nothing to Disclose

Brian Weber MD, Abstract Co-Author: Nothing to Disclose

Lawrence Delasotta MD, Abstract Co-Author: Nothing to Disclose

Brandon P. Olivieri MD, Abstract Co-Author: Nothing to Disclose

Anjeza Chukus MD, Abstract Co-Author: Nothing to Disclose

Chetan D. Rajadhyaksha MD, Abstract Co-Author: Nothing to Disclose

• Briefly describe the fundamentals of 99mTc-MDP skeletal scintigraphy and its utility in evaluation of prostate cancer metastasis . • Identify case examples of 99mTc-MDP bone scans where planar and SPECT images alone led to diagnostic uncertainty. • Observe how SPECT/CT imaging enhances diagnostic confidence through improved lesion characterization and localization in equivocal cases.

Fundamentals of skeletal scintigraphy: - 99mTc-methylene diphosphonate (99mTc-MDP) bone scan is widely used for the assessment of osseous metastatic disease in prostate cancer patients. -Abnormal uptake could be due to benign etiologies such as osteoartritis, Paget's or prior trauma as well as malignant causes such as metastatic disease. -The sensitivity and specificity of planar and single-photon emission computed tomography (SPECT) images often varies with lesion location. The Role of SPECT/CT - The addition of fusion SPECT/CT imaging to skeletal scintigraphy can not only help improve the precision of lesion localization, but it can also increase diagnostic confidence in differentiating benign versus malignant sources of increased radiotracer activity, which may decrease the need for additional imaging studies. - Demonstrate  examples of diagnostic uncertainty removed by obtaining SPECT/CT images.

http://abstract.rsna.org/uploads/2014/14019482/14019482_96hm.pdf

Malik, A, Weber, B, Delasotta, L, Olivieri, B, Chukus, A, Rajadhyaksha, C, Advancements in Skeletal Scintigraphy in Prostate Cancer with SPECT/CT: A Pictorial Review of Equivocal Cases.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14019482.html