Angela Patricia Moreno MD, Presenter: Nothing to Disclose

Jorge Andres Abreu MD, Abstract Co-Author: Nothing to Disclose

Carolina Rumie Valois, Abstract Co-Author: Nothing to Disclose

Andres Vasquez MD, Abstract Co-Author: Nothing to Disclose

Juliana Ocampo MD, Abstract Co-Author: Nothing to Disclose

Javier Andres Romero MD, Abstract Co-Author: Nothing to Disclose

1.Response Criteria in Solid Tumors or WHO criteria, designed to detect early effects of cytotoxic agents, may not provide a complete assessment of immunotherapeutic agents; 2. The appearance of measurable antitumor activity may take longer for immune therapies than for cytotoxic therapies; 3. Iplimumab monotheraphy has four distinct patterns of tumor response: a. shrinkage in baseline lesions, without new lesions; b. durable stable disease with no significant change in the size of the baseline lesions (in some patients followed by slow, steady decline in total tumor burden); c. Response after an increase in total tumor burden; and d. response in the presence of new lesions;  4. Iplimumab produces a spectrum of immune-related adverse effects: enterocolitis, hypophysitis, hepatitis, dermatitis, myopathy, pancreatitis and nephritis; 6. Specific patterns of immune-related adverse events that are detectable radiologically should be recognized early and communicated to the clinician

Introduction Why not RECIST or WHO criteria? New criteria in the assessment of Immune related tumor response Types of response. Main differences with RECIST. Are they related with favorable survival? Adverse effects related with therapy. They can be recognized radiologically? Importance in the treatment surveillance. Conclusions.  

http://abstract.rsna.org/uploads/2014/14019348/14019348_h99p.pdf

Moreno, A, Abreu, J, Rumie Valois, C, Vasquez, A, Ocampo, J, Romero, J, Multimodality Imaging of Inmunotheraphy: What Every General Radiologist Should Know.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14019348.html