Ahmed Fathy Emam MBBCh, Presenter: Nothing to Disclose

Nagy Naguib Naeem Naguib MD, MSc, Abstract Co-Author: Nothing to Disclose

Nour-Eldin Abdelrehim Nour-Eldin MD, MSc, Abstract Co-Author: Nothing to Disclose

Mohammed Ahmed Alsubhi BMBS, Abstract Co-Author: Nothing to Disclose

Katrin Eichler MD, Abstract Co-Author: Nothing to Disclose

Thomas Lehnert MD, Abstract Co-Author: Nothing to Disclose

Thomas Josef Vogl MD, PhD, Abstract Co-Author: Nothing to Disclose

To assess the volume of the Cochlea and Vestibular Labyrinth in patients presenting with Meniere Disease and to compare with the volume of normal inner ears using 3D reconstruction of MR-Imaging.

A retrospective study was performed on 135 inner ears(79 females and 56 males) with a mean age of 48.9 year(standard deviation: 25.4, range: 5 month - 88 year). Of the 135 inner ears 75 inner ear (37 right and 38 left inner ears) presented with Meniere and 60 inner ears(32 right and 28 left inner ears) diagnosed as morphologically normal. High resolution MR-Imaging was performed using a T2-weighted SPACE sequence with 0.6 mm slice thickness. 3D reconstructions were performed using Advantage Workstation for diagnostic imaging. The difference between the volumes in patients with and without Meniere was tested using the Mann-Whitney test.

Right sided Meniere: semicircular canals mean volume was 0.290 mm (SD: 0.06, Range: 0.190 – 0.430 mm3), vestibule's mean volume was 0.086 mm3(SD: 0.02, Range: 0.060 – 0.160 mm3) and Cochlea's mean volume was 0.180 mm3(SD: 0.02, Range: 0.130 – 0.240 mm3). Normal right inner Ear: semicircular canals mean volume was 0.260 mm3(SD: 0.04, Range: 0.180 – 0.340 mm3), Vestibule's mean volume was 0.070 mm3(SD: 0.01, Range: 0.050 – 0.110 mm3) and Cochlea's mean volume was 0.170 mm3(SD: 0.02, Range: 0.120 – 0.200 mm3). Left sided Meniere: semicircular canals mean volume was 0.290 mm3(SD: 0.05, Range: 0.200 – 0.410 mm3), vestibule's mean volume was 0.080 mm3(SD: 0.02, Range: 0.060 – 0.150 mm3) and Cochlea's mean volume was 0.180 mm3(SD: 0.027, Range: 0.140 – 0.260 mm3). Left normal inner ears: semicircular canals mean volume was 0.260 mm3(SD: 0.04, Range: 0.200 – 0.340 mm3), vestibule's mean volume was 0.070 mm3(SD: 0.01, Range: 0.040 – 0.090 mm3) and Cochlea's mean volume was 0.160 mm3(SD: 0.02, Range: 0.120 – 0.210 mm3). There was a statistically significant difference between the semicircular canal volume, vestibular volume and cochlear volume in inner ears affected with Meniere Disease in comparison with normal inner ears. (P value ranging between 0.002 and 0.045).  

Patients presenting with Meniere Disease show a statistically significant larger volume of the semicircular canals, vestibule and cochlea compared to patients without Meniere disease.

An increased volume of the inner ear might be responsible for Meniere disease .

Emam, A, Naguib, N, Nour-Eldin, N, Alsubhi, M, Eichler, K, Lehnert, T, Vogl, T, Volumetric Assessment of the Inner Ear in Patients Presenting with Meniere Disease  .  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14019140.html