Xiang Liu MD, Presenter: Nothing to Disclose

Wei Tian MD, PhD, Abstract Co-Author: Nothing to Disclose

There are few studies about cognitive impairment in early type 2 diabetes using fMRI technique. To evaluate cognitive dysfunction in early type 2 diabetes patients with psychological tests and BOLD fMRI. To analyze MR spectroscopy change in prefrontal cortex (PFC) and white matter abnormal by DTI.

Twenty-five patients with early type 2 diabetes mellitus and 15 demographically similar, healthy subjects were enrolled.  A series cognitive function tests including Wechs1er memory scale-revised(WMS-R) were assessed; DTI, Bold fMRI (using nback working memory task) and single-voxel MRS with TE 30 on bilateral PFC were performed. The statistic differences of psychological tests and MRS result between the two groups were evaluated by SPSS. The fMRI data were analyzed by SPM2. DTI data were processed using FSL package, Tract-Based Spatial Statistics(TBSS) to detect the FA/MD group difference.

(1) psychological tests showed that the scores of cognitive tests in diabetes group were significantly lower than those in control group. (2) fMRI examinations revealed that the activation pattern in diabetes group was similar with the control group, but less activation in prefrontal, parietal lobe. There was additional activation in right temporal lobe(including inferier temporal gyrus and parahippocampus gyrus) and anterior cingulate cortex in diabetes group. (3) MRS data showed that comparing with control group, Glx/(Cho+Cr) was significantly elevated in bilateral PFC; NAA/Cho、Glx/Cho、Glx/Cr were significantly elevated in the right PFC. Transit memory was negatively correlated with Glx/Cho (F=-0.546, P value =0.013) and Glx/(Cr+Cho) (F=-0.471, P value = 0.036). 4) DTI: patients group showed significant MD increase in right temporal WM and right superior longitudinal fasciculus (SLF) and right anterior internal capsule , FA showed decrease trend in those area in patients group.

Advanced neuroimaging techniques could detect microstructure and functional abnormalities in type 2 diabetic patients with normal appearing on conventional MR. The hypofunction in PFC in fMRI, abnormal white matter connectivity in DTI, and Glx elevation in MRS correlated with cognitive memory dysfunction, and may reveal early pathophysiological process and corresponding compensation.

Advance functional MRI technique could detect early brain cognitive damage in patient with type 2 diabetes

Liu, X, Tian, W, Cognitive Dysfunctional in Patients with Early Type 2 Diabetes: A Preliminary BOLD fMRI and MR Spectroscopy and DTI Study.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14019051.html