Xueying Ling PhD, Presenter: Nothing to Disclose

Hao Xu, Abstract Co-Author: Nothing to Disclose

Zhou-She ZHAO, Abstract Co-Author: Nothing to Disclose

chang-zheng shi, Abstract Co-Author: Nothing to Disclose

Zhong-Ping Zhang MMedSc, Abstract Co-Author: Nothing to Disclose

Li Huang, Abstract Co-Author: Nothing to Disclose

To investigate the value of ultra-high b values in evaluating brain damage in PD, bsed on the previous findings that apparent diffusion coefficient (ADC) derived from ultra-high b values possessed more diagnostic value than that from standard b values

Twenty PD patients and 18 controls underwent diffusion-weighted imaging (DWI) with standard b values (0, 1000 sec/mm2) and fifteen multiple b values (0, 30, 50, 100, 200, 300, 500, 800, 1000, 1500, 2000, 3000, 3500, 4000, 5000 sec/mm2). ADCst map was calculated from standard b-values, and ADCuh was calculated from extra-high b values (2000-5000 sec/mm2), respectively. Moreover, the maps of pure diffusion coefficient (D) and pseudo-diffusion coefficient (D*) were derived from high (200-2000 sec/mm2) and low (0-200 sec/mm2) b values, respectively. ADCst , ADCuh, D, D* of globus pallidus (GP), putamen (P), substantia nigra (SN) were achieved and compared between PD patients and controls, respectively.

ADCuh of GP, P and SN in PD patients was significantly lower than that in the control subjects (P = 0.000 or P = 0.001 p<0.001), while no significant difference was observed in ADCst, D, D* of GP, P and SN between PD patients and the controls (P > 0.05).

ADCuh of GP, P and SN were observed to decrease in PD patients, indicating that ADCuh might be an parameter for evaluating brain damage in PD patients.

ADCuh can be applied as a parameter to demonstrate brain damages in specific brain areas in PD patients.

Ling, X, Xu, H, ZHAO, Z, shi, c, Zhang, Z, Huang, L, Application of Apparent Diffusion Coefficient Values Derived from Ultra-high b-value in Parkinson’s Disease.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14018705.html