Colin J. McCarthy MD, Presenter: Nothing to Disclose

Shaunagh McDermott FFR(RCSI), Abstract Co-Author: Nothing to Disclose

Patrick Joseph Burke MBBCh, Abstract Co-Author: Nothing to Disclose

Peter F. Hahn MD, PhD, Abstract Co-Author: Stockholder, Abbott Laboratories Stockholder, Covidien AG Stockholder, CVS Caremark Corporation Stockholder, Kimberly-Clark Corporation Stockholder, Landauer, Inc

Joseph F. Simeone MD, Abstract Co-Author: Nothing to Disclose

Michael Austin Blake MBBCh, Abstract Co-Author: Editor with royalties, Springer Science+Business Media Deutschland GmbH

Pancreatic neuroendocrine tumors (PNETs) are increasingly being detected neoplasms with variable hormone production & secretion. They represent 10% of pancreatic neoplasms & can present with unusual symptoms due to secretion of hormones. Their presentations can be initially clinically challenging including such symptoms as paresthesia & confusion related to hypoglycemia from an insulinoma. We emphasize the imaging features that can be helpful to differentiate PNETs from adenocarcinoma & demonstrate the differences between functioning & non-functioning pancreatic neuroendocrine tumors. We also highlight cases in which the functional status of the tumor can be deduced from imaging alone such as gastrinoma producing imaging features of Zollinger Ellison syndrome, ACTH secreting PNET producing increase in adrenal size & serotonin secreting PNET inducing fibrosis & a pancreatic ductal stricture.

1. Introduction – cellular origin, location of tumors, malignant potential. 2. Imaging features – differences between functioning & non-functioning PNETs & adenocarcinoma. 3. The use of US, CT, MRI &Molecular imaging. 4. PNETS & their imaging features - Insulinoma & gastrinoma, Somatostatinoma, VIPoma, glucagonoma, ACTH– & serotonin- producing tumors. 5. Syndromes associated with PNETs. 6. Summary. 

http://abstract.rsna.org/uploads/2014/14018621/14018621_f9wr.pdf

McCarthy, C, McDermott, S, Burke, P, Hahn, P, Simeone, J, Blake, M, Functioning or Non-functioning? Pancreatic Neuroendocrine Tumors Sometimes Reveal Their Functional Status on Imaging.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14018621.html