Chen Yunbin MD, Abstract Co-Author: Nothing to Disclose

Wang Ren, Presenter: Nothing to Disclose

Dechun Zheng MS, Abstract Co-Author: Nothing to Disclose

Weibo Chen PhD, Abstract Co-Author: Nothing to Disclose

Xiang Zheng MS, Abstract Co-Author: Nothing to Disclose

youping xiao, Abstract Co-Author: Nothing to Disclose

Xiangyi Liu BS, Abstract Co-Author: Nothing to Disclose

Jianji Pan, Abstract Co-Author: Nothing to Disclose

The aim of this prospective study was to explore the clinical value of diffusion kurtosis imaging (DKI) in early predicting the response to neoadjuvant chemotherapy (NAC) of nasopharyngeal carcinoma at 3.0T MR.

A total of 44 patients with locally advanced NPC underwent MRI scan prior to and on the 4th, 21th (after the first cycle of chemotherapy completed), 42th (after the second cycle of chemotherapy completed) day after NAC initiation. Both the DKI parameters (corrected diffusion coefficient, D and excess diffusion kurtosis coefficient, K) and DWI parameters (apparent diffusion coefficient, ADC) were derived at each time point. The target lesions were divided into two groups (responders group, RG and non-responders group, NRG) according to lesion regression on 42th day based on RECIST 1.1. D values, K values, ADC values and its changes compared to baseline were compared between the two groups by SPSS 18.0 version software.

There is no significant difference(P=0.511) of D pre between RG (1.0087±0.038×10-3 mm2/s) and NRG (1.0490± 0.046×10-3 mm2/s) . And likewise, there shows no significant difference(P=0.084) of ADC pre between RG (0.888±0.358×10-3 mm 2/s) and NRG (0.8138±0.030×10-3mm 2/s). However, ΔD4th day were significantly greater (P=0.004)in RG( 0.3771±0.041×10-3 mm 2/s)compared to NRG(0.1979±0.046×10-3 mm2/s) .ADC21th day were significantly greater (P=0.011)in RG( 0.8886±0.0247×10-3 mm 2/s)compared to NRG(0.7999±0.0229×10-3 mm2/s) .There is no significant difference of K values or its changes between the two groups.

DKI could be a potential and more sensitive tool for early predicting response to neoadjuvant chemotherapy of nasopharyngeal carcinoma non-invasively.

DKI can early predict the treatment response of nasopharyngeal carcinoma to NAC non-invasively and this exam recommended when underlying  individual chemotherapy.  

Yunbin, C, Ren, W, Zheng, D, Chen, W, Zheng, X, xiao, y, Liu, X, Pan, J, DKI in Early Predicting the Response to Neoadjuvant Chemotherapy of Nasopharyngeal Carcinoma.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14018429.html