Mei Wei, Abstract Co-Author: Nothing to Disclose

Yaqing Chen PhD, Presenter: Nothing to Disclose

Jing Fang, Abstract Co-Author: Nothing to Disclose

xiaoyin wang, Abstract Co-Author: Nothing to Disclose

To assess liver fibrosis severity with acoustic radiation force impulse (ARFI) quantification in biliary atresia(BA) patients before Kasai surgery.

Patients with conjugated hyperbilirubinemia of unknown causes were prospectively evaluated. BA was diagnosed with laparotomy and cholangiography, liver biopsy was performed in the process of operation. Subjects without hepatobiliary diseases were recruited at the same period as controls. The pSWE with ARFI(Acuson S2000, Virtual Touch Tissue Quantification mode) was performed on all subjects before surgery and ARFI values were calculated in BA patients and control group. The difference between the two groups was statistical analyzed.

There were 27 BA patients and 20 controls in total. The ARFI values in patients were significantly faster than controls(P<0.001). Madian and mean values of ARFI according to liver fibrosis stages in BA patients were 1.16, 1.16m/s(F0), 1.70, 1.69m/s(F1), 1.67, 1.78m/s(F2), 2.21, 2.14m/s(F3) and 2.71, 2.65m/s(F4), respectively. In control group, median and mean values of ARFI were 1.11 and 1.13m/s, respectively. The correlation between ARFI and fibrosis stages was analyzed with spearman correlation coefficient, and r=0.757(P<0.001).

ARFI could reflect the liver fibrosis, and had good correlation with liver fibrosis stages in BA patients. It may become noninvasive method to predict the prognosis and determine the treatment in the future.

ARFI is a reliable noninvasive method in evaluating the severity of liver fibrosis in BA patients before Kasai surgery.

Wei, M, Chen, Y, Fang, J, wang, x, Acoustic Radiation Force Impulse (ARFI) Quantification for Assessing the Severity of Liver Fibrosis in Patients with Biliary Atresia before Kasai Surgery: Comparison with Liver Fibrosis Biopsy Pathology.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14018051.html