Min Sun Bae MD, PhD, Presenter: Nothing to Disclose

Woo Kyung Moon, Abstract Co-Author: Nothing to Disclose

Su Hyun Lee MD, Abstract Co-Author: Nothing to Disclose

Jung Min Chang MD, Abstract Co-Author: Nothing to Disclose

Ann Yi MD, PhD, Abstract Co-Author: Nothing to Disclose

Nariya Cho MD, Abstract Co-Author: Nothing to Disclose

Sung Eun Song MD, Abstract Co-Author: Nothing to Disclose

Won Hwa Kim MD, PhD, Abstract Co-Author: Nothing to Disclose

To determine the added caner yield of preoperative breast MRI in women with breast cancer detected by screening ultrasound (US)

A retrospective review of the radiology department database identified 379 women (median age 48 years, range 29 to 78) with 382 breast cancers (323 invasive, median size 1cm on US) detected by screening US who underwent preoperative bilateral breast MRI between December 2007 and December 2013. Forty-five women (12%) had a family history and/or personal history of breast cancer. Additional MRI-detected breast cancers were characterized as multifocal (additional disease within the same quadrant and/or underestimation of index cancer on US by > 2 cm compared to MRI with pathologic confirmation), multicentric (additional disease within a separate quadrant), or contralateral disease. The added cancer yield and positive biopsy rate were determined.

Fifty-three of 379 (14%) women underwent biopsy for suspicion lesions identified on preoperative breast MRI. Of these women, 21 had additional foci of cancer diagnosed with a positive biopsy rate of 40% (21/53). Cancer was identified in 19 of 48 (40%) MRI-detected ipsilateral lesions that underwent biopsy and in two of five (40%) MRI-detected contralateral lesions that underwent biopsy. Of the 21 additional sites of cancer detected, 17 (81%) represented multifocal disease, 2 (9%) represented multicentric disease, and 2 (9%) represented contralateral breast cancers. There were 20 invasive cancers and one ductal carcinoma in situ.

Preoperative breast MRI in women with screening US-detected breast cancer detected additional unsuspected sites of cancer in 6% of patients, which were mostly invasive cancers.    

The addition of preoperative breast MRI to US in women with mammographically dense breasts resulted in not only an increased cancer detection but also an increase in false-positive findings.

Bae, M, Moon, W, Lee, S, Chang, J, Yi, A, Cho, N, Song, S, Kim, W, Utility of Preoperative Breast MRI in Women with Breast Cancer Detected by Screening Ultrasound.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14017870.html