Thomas Michael Cullen MD, Presenter: Nothing to Disclose

Steven M. Bernstein MD, Abstract Co-Author: Nothing to Disclose

The purpose of this exhibit is to:  Discuss the etiology and pathophysiology of sickle cell disease. Review the characteristic and uncommon findings sickle cell disease  on MRI, CT, ultrasound, radiograph, and scintigraphy.  Discuss the complications of the disease and the radiologist's role in minimizing morbidity and mortality.  Highlight the current recommedations for imaging sickle cell patients in the acute and clinical setting, with a discussion of research regarding the use of intravenous contrast in these patients.  

The genetics and pathophysiology of sickle cell disease (SCD).  Case-based review of the systemic findings of SCD: Musculoskeletal: bone infarcts, marrow repopulation, osteomyelitis, osteonecrosis, septic arthritis. Abdominal: splenic infarct, cortical nephrocalcinosis Chest: cardiomegaly, mosiac attenutaion of lung parenchyma, ground glass opacities related to reperfusion of infarcted lung, osseous changes.  Discussion of the complications and natural progression of the disease. Review current recommendations for imaging sickle cell patients in the acute and clinical setting, including the use of intravenous contrast. 

http://abstract.rsna.org/uploads/2014/14017807/14017807_v5x8.pdf

Cullen, T, Bernstein, S, From ACS to AVN: A Comprehensive Guide to the Systemic Imaging Characteristics and Radiologic Management of Sickle Cell Disease.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14017807.html