Vincenzo Noce MD, Presenter: Nothing to Disclose

Nicola Galea MD, Abstract Co-Author: Nothing to Disclose

Andrea Fiorelli, Abstract Co-Author: Nothing to Disclose

Riccardo Rosati, Abstract Co-Author: Nothing to Disclose

Valentina Sorrentino, Abstract Co-Author: Nothing to Disclose

Marco Francone MD, Abstract Co-Author: Speakers Bureau, Bracco nv

Iacopo Carbone MD, Abstract Co-Author: Nothing to Disclose

Carlo Catalano MD, Abstract Co-Author: Nothing to Disclose

To evaluate relationships between myocardial fibrosis amount, assessed by quantitavive analysis of late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR), functional values assessed by MRI measurements and clinical data in a population of patients who underwent primary Tetralogy of Fallot repair (rToF).

We retrospectively evaluated by CMR nineteen patients with rToF, assessing clinical status at the time of MRI scan (NYHA class, exercise tolerance, history of documented clinical arrhythmias and syncope). CMR protocol comprehended bivetricular functional evalution on Steady-state precession free sequences (SSPF) obtaining volumes, ejection fraction (EF), cardiac output, myocardial mass and filling\ejection rates for both left and right ventricles (LV, RV), in addition LGE amount after Gadolinium administration was assessed on T1-weighted images.

LGE was detected in 14/19 patients, localized in RV insertions points (8/14), right ventricle outflow tract (5/14) and in the RV trabeculations (2/14). Mean LGE amount was of 2.17±0,73%, standardized by myocardial mass. Study cohort was sub-divided in LGE-positive and LGE-negative groups for statistical analysis (difference between means assessed with T-student and Wilcoxon tests; correlation assessed through Pearson and Spearman coefficients). We encountered a significant correlation between LGE amount, a reduced  RV ejection fraction (48,3±8,2%. p<0,001) and  a increased RV ESV index (54,6±5,3 ml/m2. p<0,001). LGE demonstrated a negative correlation with NYHA class and exercise tolerance (mean exercise duration 783±59 min. p<0,001).

Myocardial damage after ToF repair is frequent and is quantitatively assessable throgh CMR-LGE. In our population, LGE amount demonstrated a significant correlation with impairment of RV functional indexes and clinical data.

CMR-LGE in rToF patients correlates with a worse functional-clinical status, thus it could represent a sensible follow-up tool after surgical repair.

Noce, V, Galea, N, Fiorelli, A, Rosati, R, Sorrentino, V, Francone, M, Carbone, I, Catalano, C, Quantitative Analysis of Myocardial Fibrosis Assessed by Cardiac Magnetic Resonance in Repaired Tetralogy of Fallot: Correlation between Late Gadolinium Enhancement Amount and Clinical/Functional Data.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14017693.html