Aparna Balachandran MD, Presenter: Nothing to Disclose

Priya Ranjit Bhosale MD, Abstract Co-Author: Nothing to Disclose

Ajaykumar Chandralal Morani MD, Abstract Co-Author: Nothing to Disclose

Tara Lynn Sagebiel MD, Abstract Co-Author: Nothing to Disclose

Catherine Ellen Devine MD, Abstract Co-Author: Nothing to Disclose

Christine O. Menias MD, Abstract Co-Author: Nothing to Disclose

Vikas Kundra MD, PhD, Abstract Co-Author: License agreement, Introgen Therapeutics Inc

The proteins encoded by BRCA genes are tumor suppressors involved in DNA damage repair. With mutations of the BRCA gene, the ability to repair DNA damage is impaired, which can result in tumor development. Although breast and ovarian cancer are classically thought to be associated with BRCA mutations, other tumors may also contain such mutations like pancreatic, prostate and peritoneal cancer. Knowledge of BRCA mutations have started to affect approaches to treatment strategies. In this exhibit, we will discuss and demonstrate 1. BRCA genes and their function. 2. Epidemiology and the radiographic appearance of tumors such as breast, ovarian, prostate and pancreatic cancer, which can be seen in the setting of BRCA mutations. 3. Novel treatment strategies in patients with BRCA mutations.

1. BRCA gene product function and genetic testing 2. Epidemiology 3. Tumors associated with BRCA mutations a. Breast cancer b. Ovarian cancer c. Pancreatic cancer d. Fallopian tube cancer e. Peritoneal cancer f. Prostate cancer 4. Emerging therapy strategies in BRCA mutations  

http://abstract.rsna.org/uploads/2014/14017641/14017641_91r4.pdf

Balachandran, A, Bhosale, P, Morani, A, Sagebiel, T, Devine, C, Menias, C, Kundra, V, BRCA Associated Tumors—Not Just Breast and Ovarian Cancer.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14017641.html