Philipp Marius Paprottka, Presenter: Nothing to Disclose

Karolin Johanna Kutter, Abstract Co-Author: Nothing to Disclose

Alexander Haug MD, Abstract Co-Author: Nothing to Disclose

Christoph Gregor Trumm MD, Abstract Co-Author: Nothing to Disclose

Tobias Franz Jakobs MD, Abstract Co-Author: Speaker, Sirtex Medical Ltd Research Consultant, Sirtex Medical Ltd Speaker, Siemens AG Speaker, Terumo Corporation Speaker, Surefire Medical, Inc

Maximilian F. Reiser MD, Abstract Co-Author: Nothing to Disclose

Christoph Johannes Zech MD, Abstract Co-Author: Research Grant, Bayer AG Speaker, Bayer AG Travel support, Bayer AG Advisory Board, Bayer AG Speaker, Bracco Group Travel support, Bracco Group

To evaluate the safety of radioembolization with 90Yttrium-microspheres depending on coiling or no-coiling of aberrant/high-risk vessels.

The early and late toxicities of 566 radioembolization procedures were retrospectively analyzed according to the National Cancer Institute’s Common Terminology Criteria for Adverse Events (CTCAE v3.0). In 240 procedures the aberrant vessels were coiled prior to radioembolization and in 326 procedures we chose a more peripheral position to treat the right or left liver lobe.

According to the CTCAE criteria clinical relevant late toxicities (≥ Grade 3) could only be observed in 1% of our patients. Furthermore our statistical analysis showed significant less „any“ (p=0,0001) and „clinical relevant“ (p=0,0003) early complications for no-coiling. There was no significant difference (p > 0.05) in delayed toxicities depending on actually recommended coiling of aberrant/high-risk vessels prior to treatment in comparison to choosing a peripheral treatment position. No radiation induced liver disease was noted in 566 procedures.

Radioembolization with 90Yttrium-microspheres is a safe and effective treatment option. Performing of radioembolization without coiling aberrant vessels prior to treatment could be an alternative option for experienced centers.

Our findings could lead to a change of the pre-interventional radioembolization work-up

Paprottka, P, Kutter, K, Haug, A, Trumm, C, Jakobs, T, Reiser, M, Zech, C, Safety of Radioembolization with 90Yttrium-microspheres Depending on Coiling or No-coiling of Aberrant/High-risk Vessels.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14017520.html