Min-Ju Kim MD, Abstract Co-Author: Nothing to Disclose

Na Yeon Han, Presenter: Nothing to Disclose

Beom Jin Park MD, Abstract Co-Author: Nothing to Disclose

Deuk Jae Sung MD, Abstract Co-Author: Nothing to Disclose

Sun Hye Lee, Abstract Co-Author: Nothing to Disclose

Jun Seong Kim, Abstract Co-Author: Nothing to Disclose

To compare the incidence of disease relapse between rectal cancer patients with positive MRI-detected extramural venous invasion (mrEMVI) and those with negative mrEMVI and evaluate the relapse-free survival rates between the two groups

A total of 263 patients (166 men, 97 women; mean age: 61 years, range: 20-85 years) with biopsy proven rectal carcinoma without metastasis at initial staging were enrolled in this study. All patients were staged using preoperative 3T rectal MRI, chest/abdomen CT and PET/CT scan and underwent follow-up imaging studies after operation at least for 3 years. Two radiologists reviewed all MR images and gave a consensus regarding MRI-EMVI score (five-point scale; 0-2: negative, 3-4: positive). All follow-up images were evaluated for local recurrence or metastasis. The incidences of disease relapse were compared between the two groups (mrEMVI-positive or negative) using Chi-square test. The relapse-free survival rate was analyzed using the Kaplan-Meier method and the differences between the groups were compared using the log rank test.

Of 263 patients, there were 69 (26.2%) patients with mrEMVI-positive rectal carcinoma. Of these patients, 42% (29/69) developed local recurrence or metastases during follow-up period, which were compared to 9.8% (19/194) of those with negative mrEMVI. There was significant difference in the incidence of relapse between two groups (p< .001). The patients were followed for a median of 52 (range, 3-76) months. The 5-year relapse-free survival rate was 89.4% in patients with mrEMVI-negative rectal cancer which was significantly higher than 56.4% in patients with mrEMVI-positive rectal cancer (p < .001).

The patients with mrEMVI-positive rectal cancer demonstrated higher disease-relapse rate and lower relapse-free survival rate than those with negative mrEMVI-negative rectal cancer.

Preoperative evaluation of mrEMVI may predict the prognosis of patients with rectal carcinoma.

Kim, M, Han, N, Park, B, Sung, D, Lee, S, Kim, J, Magnetic Resonance Imaging-detected Extramural Venous Invasion: Significant Prognostic Factor in Rectal Carcinoma.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14017263.html