Jan Neumann MD, Presenter: Nothing to Disclose

Alexander Zimmermann, Abstract Co-Author: Nothing to Disclose

Christoph Schmaderer, Abstract Co-Author: Nothing to Disclose

Moritz Wildgruber MD, PhD, Abstract Co-Author: Nothing to Disclose

Ernst J. Rummeny MD, Abstract Co-Author: Nothing to Disclose

Reinhard Meier MD, PhD, Abstract Co-Author: Nothing to Disclose

The aim of this study was to investigate an Indocyanine Green (ICG)-enhanced optical imaging (OI) system to differentiate between haemodynamic relevant stenosis looking at the microcirculation of the hand in patients with symptoms of upper extremity ischemia and volunteers.

3 female Patients (mean age = 42.3) with clinical suspicion of upper extremity peripheral artery disease including claudication, rest pain, or tissue loss and 10 healthy volunteers were examined with a clinically new available ICG-enhanced optical imaging system (mivenion GmbH, Germany). The microcirculation of both hands was graded objectively by three independent radiologists on a 3-point-ordinate scale (0: normal blood flow, 1: mild, 2: severe alteration of microcirculation). Results were correlated with CT, MRI or angiography as standard of reference. 

All patients showed in OI an alteration of microcirculation of the affected hand in comparison to the healthy contralateral hand and in comparison to the healthy volunteers. CT, MRI or angiography as standard of reference confirmed a stenosis of upper extremeties arteries, dialysis (AV) shunt malfunction or vascular anomalies. The differences were significant between the patient group compared to the control group (p<0.05).

Our preliminary data shows, that optical imaging allows to differentiate between haemodynamic relevant stenosis looking at the microcirculation of the hand in patients with symptoms of upper extremity ischemia. OI might be of substantial added value to clinical examination due to its non-invasiveness, low costs and easy availability. 

OI is a fast, inexpensive, non-invasive and non-ionizing imaging modality which has potential to be helpful for characterization of the cutaneous microvascularization in patients with symptoms of upper extremity ischemia.

Neumann, J, Zimmermann, A, Schmaderer, C, Wildgruber, M, Rummeny, E, Meier, R, Preliminary Results: Functional and Morphological Evaluation of Hand Microcirculation of the Hand in Patients with Symptoms of Upper Extremity Ischemia by Means of a 2D Optical Imaging System.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14017251.html