Matthias Teufel, Abstract Co-Author: Nothing to Disclose

Katharina Schmidt, Abstract Co-Author: Nothing to Disclose

Ines Ketelsen, Abstract Co-Author: Nothing to Disclose

Ute Graepler-Mainka, Abstract Co-Author: Nothing to Disclose

Joachim Riethmuller MD, Abstract Co-Author: Nothing to Disclose

Juergen F. Schaefer MD, Presenter: Nothing to Disclose

Ilias Tsiflikas MD, Abstract Co-Author: Nothing to Disclose

Konstantin Nikolaou MD, Abstract Co-Author: Speakers Bureau, Siemens AG Speakers Bureau, Bracco Group Speakers Bureau, Bayer AG

The aim of this retrospective analysis was the evaluation of the Helbich-BallaScore (HBS) – already reviewed in comparison to CT – and a self-developed MRI-Score (MRS) in reference to the interobserver reliability and the valuation of the clinical impact.

A standardized lung MRI at 1.5 T and a pulmonary function test were performed in 51 patients (mean 11.4 y, SD 3.1 y) on the same day. The MRI was independently and blinded scored by three radiologists with different experience (1 highest, 3 lowest) using the non modified HBS system. Additionally the examinations were analyzed by the same readers with the MRS system that was adapted from the Crispin Norman Score (CNS). In difference to the CNS the MRS points were given on the basis of lung lobes, and the category “centrilobular nodules” was added. To evaluate interobserver reliability Pearson’s correlation coefficient (R) was calculated. Scores were also correlated with forced expiratory volume in one second (FEV1). The possible prognostic value of the scores was estimated using ROC analysis for significant decrease of FEV1 (> 3%/year) over period of 2 years.

Both scores were reproducible (R = 0.85 to 0.88 for HBS and 0.85 to 0.90 for MRS). The scores correlated significantly with FEV1 (HBS: R= - 0.50 to -0.58 and MRS: -0.51 to -0.63, P<0.001). The highest value in both scores was achieved by reader 1. With a baseline FEV1 of 50% to 100% 7/30 patients showed a decrease >3%/year. In this group the mean AUC for centrilobular nodules and bronchiectases of the MRS was 0.96 and 0.87, and 0.84 for bronchiectases of the HBS.

The results indicate that both scores are reproducible and clinical useful. The MRS may have the higher prognostic performance.

Application on thoracic/pulmonal MRI in patient suffering from cystic fibrosis for follow up and therapy monitoring. Detection and evaluation of the severity of pulmonal findings in cystic fibrosis and other pulmonary diseases.

Teufel, M, Schmidt, K, Ketelsen, I, Graepler-Mainka, U, Riethmuller, J, Schaefer, J, Tsiflikas, I, Nikolaou, K, Lung-MRI in Children with Cystic Fibrosis (CF): Evaluation of Two Diagnostic-scores Concerning Interobserver Reliability and Valuation of Clinical Impact.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14017130.html