Yoo Jin Hong MD, Presenter: Nothing to Disclose

Donghyun Hong MS, Abstract Co-Author: Nothing to Disclose

Chul hwan Park MD, Abstract Co-Author: Nothing to Disclose

Jin Hur MD, Abstract Co-Author: Nothing to Disclose

Young Jin Kim MD, Abstract Co-Author: Nothing to Disclose

Hye-Jeong Lee MD, Abstract Co-Author: Nothing to Disclose

Sae Rom Hong MD, Abstract Co-Author: Nothing to Disclose

Young Joo Suh MD, Abstract Co-Author: Nothing to Disclose

Yun Jung Kim MD, Abstract Co-Author: Nothing to Disclose

Dong Jin Im, Abstract Co-Author: Nothing to Disclose

Byoung Wook Choi MD, Abstract Co-Author: Nothing to Disclose

Purpose To validate extracellular volume (ECV) fraction using dual energy computed tomography (CT) and to compare it with contrast enhanced magnetic resonance imaging (MRI) and histologic findings.  

Dilated cardiomyopathy rabbit (DCR, male adult New Zealand White rabbit, 3−4 kg) model was made by injecting doxorubicin (Doxorubicin Hydrochloride, Cayman) at doses of 1.0mg/kg twice a week for 16weeks. Every rabbit underwent both dual-energy CT (Siemens Somatom, Forchheim) and cardiac MRI (Siemens Magnetom, Erlangen) within two hours with pre-/post- T1 mapping using modified Look-Locker inversion recovery (MOLLI) sequence, LGE, and cine MRI on a clinical 3-T system. Rabbits underwent CT and MRI examination before drug administration (Control group) and two week interval until 16 weeks after DCR modeling. CT ECV was quantitatively assessed by measuring Hounsfield units (HUs) in the septum in a short-axis view on iodine maps with the following equation ECV= (ΔHUmyocardium/ΔHUblood) × (1- hematocrit (Hct)), ΔHU= HU post-contrast -HUpre-contrast. MR ECV was also calculated at the same area using the following equation: ECV = [(1/T1post contrast myocardium)-(1/T1pre-contrast myocardium)/(1/T1post-contrast blood)-(1/T1pre-contrast blood)]×(1-Hct)

Three control and seventeen DCR model were included. The mean CT ECV values were significantly elevated at the 6th week and continued to rise until the 16th week of the DCR modeling (pre vs. 6weeks vs. 16 weeks; 28.1±2.2 vs. 35.3±6.8 vs. 41.5±1.4, p-value<0.05) and there was a good correlation between CT ECV and MR ECV (r=0.803, p-value<0.001) and between CT ECV and degree of fibrosis (r=0.79, p-value<0.001).

Dual energy CT is a noninvasive feasible study to measure diffuse myocardial fibrosis quantitatively using CT ECV without misregistration error.

CT ECV using dual energy CT is a noninvasive useful method for a quantification of diffuse myocardial fibrosis which can replace endomyocardial biopsy.

Hong, Y, Hong, D, Park, C, Hur, J, Kim, Y, Lee, H, Hong, S, Suh, Y, Kim, Y, Im, D, Choi, B, Assessment of Extracellular Volume Fraction in Doxorubicin Induced Dilated Cardiomyopathy Rabbit Models Using Dual Energy Computed Tomography: Comparison with Contrast Enhanced Magnetic Resonance Imaging and Histologic Findings.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14017068.html