Jeong Min Lee MD, Presenter: Research Grant, Guerbet SA Equipment support, Siemens AG Research Grant, Bayer AG

Dong Ho Lee MD, Abstract Co-Author: Nothing to Disclose

Ernst Klotz DiplPhys, Abstract Co-Author: Employee, Siemens AG

Joon Koo Han MD, Abstract Co-Author: Nothing to Disclose

Byung Ihn Choi MD, PhD, Abstract Co-Author: Research Consultant, Samsung Electronics Co Ltd

Mi Hye Yu MD, Abstract Co-Author: Nothing to Disclose

To determine the feasibility of multiphasic dynamic CT including multiple arterial phases for evaluation of liver tissue perfusion characteristics using the dual maximum slope model in patients with chronic liver disease compared with perfusion CT (PCT) as the standard of reference

PCT was performed in 23 patients with chronic liver diseases using Xenetix 370. Ten of these 23 patients were classified as the validation group in order to verify the method of obtaining the perfusion parameters using multiphasic dynamic CT, and the remaining 13 patients were classified as the evaluation group. Five–phase, dynamic CT including unenhanced, triple-arterial phases including information regarding the peak aortic and splenic enhancement and the portal phase, were selected in order to obtain perfusion parameters of liver parenchyma using a the dual maximum slope method. Those selected CT datasets and the whole PCT data sets were analyzed using the dedicated perfusion software (VPCT body; Siemens Healthcare) for estimating the perfusion parameters. Comparison between the perfusion parameters calculated from the multiphasic dynamic CT datasets and those of PCT was made using the intraclass correlation coefficient.

All of the perfusion parameters of patient liver parenchyma obtained by five-phase images in the 23 patients, did not differ significantly compared with those of PCT. They showed very high agreement with PCT (ICCs > 0.80, P-value < 0.01) in both the validation and the evaluation groups.

It was feasible to obtain perfusion parameters of the liver using multiphasic dynamic CT scans, and the perfusion parameters using the dynamic CT scans and the dual maximal slope model were comparable to those of perfusion CT.  

Dynamic CT scans including multiple arterial phase imaging using the dual maximal slope model is able to provide not only morpholigic information but also perfusion parameters of the liver which were comparable to those of perfusion CT.Thereore, it can be feasible to use this approach using dynamic CT and the dual maximum slope model for evaluation of liver fibrosis, liver cirrhosis and portal hypertension.  

Lee, J, Lee, D, Klotz, E, Han, J, Choi, B, Yu, M, Multiple Arterial Phase Dynamic CT for Evaluation of Liver Tissue Perfusion Characteristics Using the Dual Maximum Slope Model: Correlation with Perfusion CT in Patients with Chronic Liver Disease.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14016916.html