Wenhuan Li MD, Presenter: Nothing to Disclose

Kuncheng Li MD, Abstract Co-Author: Nothing to Disclose

Xiaolian Zhu, Abstract Co-Author: Nothing to Disclose

Nan Chen MD, Abstract Co-Author: Nothing to Disclose

Qi Yang MD, Abstract Co-Author: Nothing to Disclose

Xiangying Du MD, Abstract Co-Author: Nothing to Disclose

To identify the optimal dual energy computed tomography (DECT) series for detection of myocardial perfusion defects, by comparing all different DECTseries (iodine mapping, monoenergetic series, nonlinearly blended series, linearly blended series, and 100KV series), using 13NH3 positron emission tomography (PET) as reference standard.

This study was approved by the local ethics committee, and written informed consent was obtained from each patient. Nineteen prospectively enrolled patients, with known or high likelihood of coronary heart disease, underwent both cardiac DECT and 13NH3 PET acquisition at rest. The DECT data were reconstructed as iodine mapping, monoenergetic series, nonlinearly blended series, linearly blended series, and 100kV series. The myocardial perfusion defects on all different DECT series was visually assessed by 2 observers, using standard 17-segment model. Per-segment agreement between modalities was investigated with kappa statistics. The comparison of all different DECT series vs. PET was mainly based on receiver operating characteristic (ROC) curve analysis.

A total of 323 segments (100%) of all 19 patients were analyzed. Iodine mapping showed the largest area under ROC curve (AUC) (0.897±0.021,P<0.001), best correlation with 13NH3 PET (K=0.777, P<0.001), and best diagnostic accuracy (96.7% sensitivity, 82.7% specificity, 88.1% positive predictive value, 95.0% negative predictive value, and 90.7% accuracy) among all different DECT series.

Iodine mapping is superior to other DECT series for the visualization of myocardial perfusion defects.

Iodine mapping is a powerful DECT series for detecting myocardial perfusion defects and is recommended in evaluation of myocardial blood supply.

Li, W, Li, K, Zhu, X, Chen, N, Yang, Q, Du, X, A Performance Comparison of all Different DECT Series for Assessment of Myocardial Blood Supply Using 13NH3 PET as the Reference Standard.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14016418.html