Brenna Ann Talkin Chalmers MD, Presenter: Nothing to Disclose

Linda Hovanessian-Larsen MD, Abstract Co-Author: Nothing to Disclose

Bhushan Desai MBBS, MS, Abstract Co-Author: Nothing to Disclose

Darryl Hwang PhD, Abstract Co-Author: Nothing to Disclose

Samantha Delapena, Abstract Co-Author: Nothing to Disclose

Sandy Chia-En Lee MD, Abstract Co-Author: Nothing to Disclose

Edward G. Grant MD, Abstract Co-Author: Research Grant, Bracco Group Research Grant, General Electric Company Medical Advisory Board, Nuance Communications, Inc

1. To understand the basics of contrast enhanced ultrasound (CEUS) and Shear Wave Elastography (SWE). 2.To investigate the role of CEUS and SWE as a potential response assessment biomarker to neoadjuvant chemotherapy (NAC) in breast cancer by evaluating changes in tumor size, perfusion characteristics, and tissue stiffness before (baseline) and 2-3 weeks post-NAC initiation. 3. To assess the agreement between CEUS and SWE based classification rule and pathologically determined treatment response. 4. To determine the agreement between different imaging modalities (including conventional US, MRI, SWE). 5. To illustrate pictorial cases where CEUS and SWE are useful for therapy monitoring of breast cancer patients on NAC.  

I. Background and Significance II. Literature review III. Limitations of conventional imaging modalities IV. Clinical utility of CEUS and SWE V. Technical note: Imaging data acquisition methodology (qualitative and quantitative) VI. Evaluating treatment response using different imaging modalities VII. Clinical case examples of studies done at our institution  

http://abstract.rsna.org/uploads/2014/14016053/14016053_tho2.pdf

Chalmers, B, Hovanessian-Larsen, L, Desai, B, Hwang, D, Delapena, S, Lee, S, Grant, E, Role of Contrast Enhanced Ultrasound and Shear Wave Elastography for Assessment of Treatment Response to Neoadjuvant Chemotherapy in Breast Cancer – Preliminary Results.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14016053.html