Applications of FDG-PET and Arterial Spin Labeling MR Imaging in Quantification of Cerebral Metabolic Activity and Blood Flow in Neurodegenerative Diseases: Comparison of FDG-PET and ASL

NRE220

Applications of FDG-PET and Arterial Spin Labeling MR Imaging in Quantification of Cerebral Metabolic Activity and Blood Flow in Neurodegenerative Diseases: Comparison of FDG-PET and ASL

Education Exhibits

Presented in 2014

Sina Houshmand MD, Presenter: Nothing to Disclose

Ali Salavati MD, MPH, Abstract Co-Author: Nothing to Disclose

Benjapa Khiewvan, Abstract Co-Author: Nothing to Disclose

Thomas J. Werner, Abstract Co-Author: Nothing to Disclose

Sudipto Dolui PhD, Abstract Co-Author: Nothing to Disclose

Abass Alavi MD, Abstract Co-Author: Nothing to Disclose

To review applications of currently available FDG-PET quantification techniques in assessment of cerebral metabolic activity of Alzheimer’s disease patients. To review and compare arterial spin labeled MR imaging with FDG-PET in diagnosis and characterization of Alzheimer’s disease.

Alzheimer’s disease (AD) is a neurodegenerative disease associated with alterations in cerebral blood flow (CBF) in different regions of brain. These changes have been well correlated with cerebral metabolism abnormalities using 18F-fluorodeoxyglucose positron emission tomography (FDG PET). Arterial spin labeling (ASL) MRI which utilizes magnetically labeled blood water as a tracer for CBF quantification has shown to be a potential non-invasive biomarker for AD over the last several years. In this review we will discuss applications of these two modalities and compare their characteristic features and potential for diagnosis of AD and its spectrum. 1. FDG-PET i. Pathophysiology of changes in FDG-PET images ii. Pattern of changes iii. Correlation with clinical severity iv. Use as therapeutic endpoint v. Sensitivity and specificity vi. Quantitative methods 2. ASL MRI i. Technical aspects of ASL ii. Regions of hypoperfusion iii. Correlation with PET

http://abstract.rsna.org/uploads/2014/14015859/14015859_rbgp.pdf

Houshmand, S, Salavati, A, Khiewvan, B, Werner, T, Dolui, S, Alavi, A, Applications of FDG-PET and Arterial Spin Labeling MR Imaging in Quantification of Cerebral Metabolic Activity and Blood Flow in Neurodegenerative Diseases: Comparison of FDG-PET and ASL. Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14015859.html