Kum Ju Chae, Presenter: Nothing to Disclose

Hyunnyeong Jung MD, Abstract Co-Author: Nothing to Disclose

Gong Yong Jin MD, PhD, Abstract Co-Author: Nothing to Disclose

Young Sun Lee, Abstract Co-Author: Nothing to Disclose

Su Bin Chon, Abstract Co-Author: Nothing to Disclose

Keun-Sang Kwon, Abstract Co-Author: Nothing to Disclose

Young Min Han MD, Abstract Co-Author: Nothing to Disclose

To compared CT findings, pulmonary function tests (PFT), and survival rate of usual interstitial pneumonia (UIP) with those of combined pulmonary fibrosis and emphysema (CPFE)

This study was approved by the institutional review board and informed consent was waived. From January 2004 to December 2009, among 105 patients who underwent open lung biopsy due to interstitial lung disease, 55 patients diagnosed as UIP or CPFE pathologically were finally included in this study. We reviewed the CT findings and clinical characteristics including pulmonary function test of 55 patients; biopsy proven UIP with typical or probable UIP pattern in CT (n=38), biopsy proven UIP or CPFE with CPFE pattern in CT (n=17). The extent of honeycombing on CT was visually assessed using five point scale by two observers independently. Clinical characteristics including PFT were analyzed by Student t-test. Differences of 5-year survival rate according to extent of honeycombing on CT for each group were calculated from Kaplan-Meier analysis.

The five year survival rate between UIP and CPFE group was not significantly different (P=0.406). Also, physiologic variables such as FEV1, FVC, FEV1/FVC and DLCO in two groups were not independent risk factors to determine survival rate. The extent of honeycombing on CT between two groups wasn’t significantly different (P=0.140). However, the extent of honeycombing over 25% on CT was an important prognostic factor to determine survival rate (P=0.041, 95% CI;1.032-4.456) regardless of UIP or CPFE patients; median survival rate of honeycomb extent over 25% (17.3 months), <25% (57.2 months).

The larger extent of honeycombing at CT is associated with poor prognosis of CPFE and UIP patients.

1. Quantification of honeycombing extent on CT in UIP and CPFE patients is important for prognosis prediction. 2. CPFE patients proved to be have two pathologic patterns (UIP and CPFE).  

Chae, K, Jung, H, Jin, G, Lee, Y, Chon, S, Kwon, K, Han, Y, Comparison of Fibrosis Extent on CT, Pulmonary Function Test, and Survival Rate between Usual Interstitial Pneumonia (UIP) and Combined Pulmonary Fibrosis and Emphysema (CPFE).  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14015674.html