Lisa P. Lavelle MBBCh, FFR(RCSI), Presenter: Nothing to Disclose

Sinead Helena McEvoy MBBCh, FFR(RCSI), Abstract Co-Author: Nothing to Disclose

Jan Frank Gerstenmaier FFR(RCSI), FRCR, Abstract Co-Author: Nothing to Disclose

Elaine Ni Mhurchu MBBCh, Abstract Co-Author: Nothing to Disclose

Aoife Mc Carthy, Abstract Co-Author: Nothing to Disclose

Niall Swan, Abstract Co-Author: Nothing to Disclose

Ronan Killeen, Abstract Co-Author: Nothing to Disclose

Eric John Heffernan MBBCh, FRCR, Abstract Co-Author: Nothing to Disclose

Stephen John Skehan MBBCh, Abstract Co-Author: Nothing to Disclose

Dermot E. Malone MD, Abstract Co-Author: Nothing to Disclose

Robert Gerard Gibney MBBCh, Abstract Co-Author: Nothing to Disclose

IgG4-related disease is a systemic condition, first recognized in 2003. It is characterized by focal or diffuse infiltration and encasement by inflammatory and fibrotic tissue. Histologically a dense lymphoplasmacytic infiltrate rich in IgG4 positive plasma cells is seen. The pancreas is the most commonly involved organ, however it can involve multiple other structures including; bile ducts, retroperitoneum, kidneys, aorta, periorbital tissue, salivary glands, pituitary, thyroid gland, pericardium, skin and lymph nodes. The aim of this exhibit is to provide a multimodality illustration of the spectrum of imaging findings in IgG4 related disease facilitating prompt diagnosis and assessment for further organ involvement.

To describe the common and uncommon manifestations of IgG4-related disease using an anatomic approach from the top down with radiological pathological correlation where appropriate: 1.Head and Neck: Periorbital tissue, pituitary, thyroid gland, cranial nerve involvement 2.Mediastinal: Inflammatory pseudotumor, central airway disease, interstitial pneumonia, pleural thickening 3.Hepatobiliary: Focal, diffuse and mass forming pancreatitis, IgG4-related cholangitis 4.Renal:Tubulointerstitial nephritis 5.Retroperitoneum:Periaortic, periureteral or plaque like mass involvement

http://abstract.rsna.org/uploads/2014/14015433/14015433_skby.pdf

Lavelle, L, McEvoy, S, Gerstenmaier, J, Ni Mhurchu, E, Mc Carthy, A, Swan, N, Killeen, R, Heffernan, E, Skehan, S, Malone, D, Gibney, R, IgG4-Related Disease, the Great Mimic; Imaging Manifestations from the Top Down.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14015433.html