You Seon Song, Presenter: Nothing to Disclose

In Sook Lee, Abstract Co-Author: Nothing to Disclose

Jeung Il Kim MD, PhD, Abstract Co-Author: Nothing to Disclose

In Seong Kim PhD, Abstract Co-Author: Nothing to Disclose

To evaluate the efficacy of intravoxel incoherent motion (IVIM) diffusion-weighted (DW) MR imaging for differentiating benign and malignant bone and soft tissue tumors

From June to December 2013, 304 patients underwent musculskeletal MR imaging including IVIM DW sequence with ten b values (0-1000 sec/mm2). Among them, 73 consecutive patients (38 women, 35 men; age range, 1-84 years; mean age, 47 years) with bone or soft tissue mass lesions were included. All ROIs about the mass were manually positioned on parametric maps obtained with software (MatLab), and then apparent diffusion coefficient (ADC) and IVIM-derived parameters (Dslow, Dfast, perfusion fraction) were calculated. The ADC value, Dslow, Dfast and perfusion fracture (PF) parameters were compared between the benign and malignant group by using independent samples t-test and ROC analysis.

41 patients had malignant tumors and 32 had benign tumors. The ADC value and Dslow parameter were statistically significant factors (p<0.05) in differentiating between benign and malignant bone or soft tissue tumors. By ROC analysis, Dslow (AUC, 0.801; SE, 0.0579; 95% confidence interval, 0.691-0.885; p<0.0001; cut-off value, 1.15x10-3mm2/sec; sensitivity, 80.5%; specificity, 75%) demonstrated higher significancy and specificity than the ADC value (AUC, 0.739; SE, 0.0646; 95% confidence interval, 0.623-0.834; p=0.0002; cut-off value<1.5x10-3mm2/sec; sensitivity, 82.9%; specificity, 62.5%).

IVIM-derived Dslow values demonstrated superior performance compared with the ADC value in differentiating benign from malignant bone and soft tissue tumors.

IVIM diffusion-weighted MR imaging is useful in diagnosing musculoskeletal tumors since it reflects pure diffusion effect of the tumor.

Song, Y, Lee, I, Kim, J, Kim, I, The Efficacy of Intravoxel Incoherent Motion Diffusion-weighted MR Imaging in the Evaluation of Benign and Malignant Bone and Soft Tissue Tumors.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14015266.html