Adam Landon Sipe MD, Presenter: Nothing to Disclose

Sarah E. Connolly MD, Abstract Co-Author: Nothing to Disclose

Tammie Smith Benzinger MD, PhD, Abstract Co-Author: Research Grant, Eli Lilly and Company Researcher, Eli Lilly and Company Researcher, F. Hoffmann-La Roche Ltd

Jonathan Edward McConathy MD, PhD, Abstract Co-Author: Speakers Bureau, Eli Lilly and Company Research Consultant, Eli Lilly and Company Research Consultant, General Electric Company Research Consultant, Blue Earth Diagnostics Ltd Research Consultant, Siemens AG

Michelle M. Miller-Thomas MD, Abstract Co-Author: Nothing to Disclose

Amyloid is a class of aggregated proteins that occur in both common and uncommon diseases of the central nervous system (CNS). This exhibit will aim to: 1. Familiarize the radiologist with the pathophysiology and clinical presentation of amyloid-related diseases in the CNS including Alzheimer’s type dementia, cerebral amyloid angiopathy, and cerebral amyloidoma. 2. Discuss the imaging appearance of these three CNS amyloid-related diseases in a case-review format with self-assessment questions.  The goal is to assist the radiologist with distinguishing among these three amyloid related diseases and other diseases with similar clinical presentations. 

Clinical cases of Alzheimer’s type dementia, cerebral amyloid angiopathy, and cerebral amyloidoma are reviewed emphasizing: Clinical presentation Role of amyloid in the pathophysiology of the disease Imaging appearance utilizing the following modalities                a. Computed tomography (CT)                b. Magnetic resonance imaging (MRI)                c. Pittsburgh compound B (11C-PiB) and 18F-Florbetapir positron emission tomography (PET)  

http://abstract.rsna.org/uploads/2014/14015258/14015258_opxl.pdf

Sipe, A, Connolly, S, Benzinger, T, McConathy, J, Miller-Thomas, M, Multimodality Review of Amyloid-Related Diseases of the Central Nervous System.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14015258.html