Ayako Hino-Shishikura, Abstract Co-Author: Nothing to Disclose

Ukihide Tateishi MD, PhD, Presenter: Nothing to Disclose

Tomohiro Yoneyama, Abstract Co-Author: Nothing to Disclose

Ikuo Torii, Abstract Co-Author: Nothing to Disclose

Tomio Inoue MD, PhD, Abstract Co-Author: Nothing to Disclose

To compare [62]Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) (62Cu-ATSM) PET/CT imaging and the diffusion weighted imaging (DWI) of brain tumors.

[62]Cu-ATSM PET/CT and DWI were performed on 40 brain tumors (low grade glioma (n=13), glioblastoma (GBM) (n=20), Primary central nervous system lymphoma (PCNSL) (n=7)).The 62Cu-ATSM PET/CT uptake and signal intensity of DWI were evaluated using standard uptake value (SUV) and apparent diffusion coefficient (ADC). The correlation of SUV and ADC for all tumors, and the difference of SUV and ADC between each tumor was also evaluated.

[62]Cu-ATSM uptake and signal intensity of DWI was high in GBM and PCNSL compared to low grade glioma. In GBM and PCNSL, the patterns of locations showing high [62]Cu-ATSM uptake and high signal intensity of DWI were similar. Inverse correlation was found between maximum SUV (SUVmax) and minimum ADC (ADCmin) (r = -0.58, p<0.0001), and between tumor/brain ratio (T/B ratio) and ADCmin for all tumors (r =-0.52, p<0.0001). Both SUVmax and T/B ratio were significantly high in GBM than in low grade glioma (p=0.03), and were significantly high in PCNSL than in GBM (p=0.03). ADCmin was significantly low in GBM than in low grade glioma (p=0.01), while no significant difference was found between GBM and PCNSL (p=0.90).

Both [62]Cu-ATSM PET/CT and DWI were considered to be good diagnostic tests for the grading glioma. [62]Cu-ATSM PET/CT provided additional diagnostic information to differentiate GBM and PCNSL.

For the differential diagnosis of GBM and PCNSL, SUV measurement of [62]Cu-ATSM PET/CT considered tomay provide additional information.

Hino-Shishikura, A, Tateishi, U, Yoneyama, T, Torii, I, Inoue, T, Comparison of [62]Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET/CT Imaging and Microscopic Diffusion Capacity in Brain Neoplasms.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14015208.html