Lu Lin MD, Presenter: Nothing to Disclose

Yining Wang MD, Abstract Co-Author: Nothing to Disclose

Jian Cao MD, Abstract Co-Author: Nothing to Disclose

Lingyan Kong MD, Abstract Co-Author: Nothing to Disclose

Zheng Yu Jin MD, Abstract Co-Author: Nothing to Disclose

Jing An, Abstract Co-Author: Research collaboration, Siemens AG

Tianjing Zhang, Abstract Co-Author: Nothing to Disclose

To investigate the diagnostic value of 3.0T motion-corrected single-shot phase sensitive inversion recovery (PSIR) late gadolinium enhancement (moco-LGE) compared with the conventional segmented breath-held LGE (bh-LGE).

 In a consecutive cohort of 36 patients referred for clinical enhanced cardiac MR, bh-LGE and moco-LGE were collected contemporarily with identical image parameters using a 3.0T scanner. The moco-LGE was acquired just after the bh-LGE while the patients were asked to breathe freely. Images were randomized and scored for image quality (1-very poor and not analyzable, 2-poor, 3-acceptable, 4-good, 5-very good) and diagnostic confidence for myocardial LGE (1-low confidence, 2-some confidence, 3-high confidence) separately base on the American Heart Association 17-segmented model. In patients with diagnostic image quality and definite LGE, the myocardial LGE mass was quantified. Paired t test was used to compare the image quality, diagnostic confidence. Linear regression and correlation plots were used to compare LGE mass.

35 patients had regular heart rate (HR), the mean HR was 72±12 beats per minute (bpm). The other one patient had atrial fibrillation rhythm. In all the patients, the moco-LGE with free-breathing had similarly high image quality (4.0±0.9 vs 3.9±0.9, P=0.350), and diagnostic confidence (2.8±0.3 vs 2.8±0.4, P=0.893) compared with bh-LGE. A total of 9 patients with marked image artifacts in bh-LGE for arrhythmia or respiratory motion, moco-LGE had significantly higher image quality (3.8±0.8 vs 3.1±0.9, P=0.000) and confidence(2.8±0.2 vs 2.5±0.4, P=0.000). The myocardial LGE mass was quantified and compared in 12 patients, the results correlated highly (R2=0.95, P=0.000) without bias.

In general, moco-LGE and bh-LGE have similar image quality and myocardial LGE quantification. In vulnerable patients with marked artifacts of bh-LGE, moco-LGE probably has higher image quality and diagnostic confidence.

Motion corrected single shot PSIR LGE is a promising clinical tool for detecting myocardial fibrosis, especially for vulnerable patients with arrhythmia or respiratory motions.

Lin, L, Wang, Y, Cao, J, Kong, L, Jin, Z, An, J, Zhang, T, 3.0T Motion-corrected Single-shot Phase Sensitive Inversion Recovery (PSIR) Late Gadolinium Enhancement (LGE) in Free-breathing Patients Compared with Conventional Segmented Breath-held LGE.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14015204.html