Zhenpeng Peng, Presenter: Nothing to Disclose

Shiting Feng MD, Abstract Co-Author: Nothing to Disclose

Ziping Li MD, PhD, Abstract Co-Author: Nothing to Disclose

To estimate the ability of T1 mapping of liver and the quantitative liver–muscle contrast ratio (Q-LMC) on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging for the estimation of liver function.

Institutional Review Board approval and written informed consent were obtained.94 patients underwent MRI with a 3.0T system before and at 20 minutes after Gd-EOB-DTPA administration.73 were Child-Pugh class A(CPA) ,14 were B(CPB) and 7 were C(CPC).T1 maps were acquired using three dimensional spoiled gradient echo sequences with two different flip angles (2 and 11 ) and a fixed TR/TE (4.4ms/1.2ms). Liver T1 values were obtained using a T1 processing tool (MapIT software). T1 relaxation time of liver and reduction rate of T1 relaxation time between pre- and post-contrast enhancement were measured. The quantitative liver–muscle contrast ratio (Q-LMC) was calculated using the signal intensities of the liver and erector spinae with fat-suppressed FLASH T1-weighted sequence images. The one-way anova and pearson correlation were used for comparisons between the 2 methods.

Post-contrast T1 relaxation times of liver were significantly reduced. The reduction rate of T1 relaxation time in CPA/CPB/CPC were 77.6±8.4%,62.6±8.5%,50.7±12.5%. The difference between each group were significant (P<0.05). The increase Q-LMC in CPA/CPB/CPC were 59.4±8.5%,48.5±6.3%,46.2±6.2%. The difference between CPA/CPB and CPA/CPC were significant (P<0.05), but the difference between CPB/CPC was not significant(P>0.05).The pearson correlation coefficient of the reduction rate of T1 relaxation time and the Q-LMC were -0.648 and -0.526.

Both the T1 mapping of liver and the Q-LMC before and after Gd-EOB-DTPA administration can help estimate liver function. The reduction rate of T1 relaxation time was the better index of liver function than the Q-LMC.

The reduction rate of T1 relaxation time was the better index of liver function than the Q-LMC.

Peng, Z, Feng, S, Li, Z, Estimation of Liver Function on Gd-EOB-DTPA-Enhanced Magnetic Resonance Imaging: Compare with T1 Mapping and the Quantitative Liver–Muscle Contrast Ratio.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14015175.html