Sidhartha Tavri MBBS, Presenter: Nothing to Disclose

Mohammad Ghasemi-rad MD, Abstract Co-Author: Nothing to Disclose

Rahul Anil Sheth MD, Abstract Co-Author: Nothing to Disclose

Richard L. Hesketh, Abstract Co-Author: Nothing to Disclose

Basak Uygun PhD, Abstract Co-Author: Nothing to Disclose

Berk Usta PhD, Abstract Co-Author: Nothing to Disclose

David S. Kong PhD, Abstract Co-Author: Nothing to Disclose

Rahmi Oklu MD, PhD, Abstract Co-Author: Nothing to Disclose

1) Review various methods of ‘decellularization’ technologies in general and specifically in liver. 2) Review the current status of stem cell therapy in regenerative medicine specifically focusing on hepatocyte derivation from pluripotent cells and fibroblasts.

1. List the current challenges in the definitive management of liver failure with orthotopic transplantation by a brief review of UNOS/OPTN data. 2. Decellularization – definition – overview of various methods of decellularizing tissue/organs including physical, chemical and enzymatic methods with their limitations, with focus on liver – briefly illustrate role of irreversible electroporation as an alternative method with literature review 3. Stem cell therapy – review the various autologous and allogeneic cell sources i.e., embryonic, fetal, inducible pluripotent stem cells, adult derived stem cells, primary tissue or organ-derived cells – review seeding techniques and list the endpoints of tissue engineered organs – describe advantages of a decellularized scaffold for stem cell therapy 4. The role of interventional radiologists in targeted decellularization of tissues, targeted stem cell therapy and monitoring its fate by imaging in vivo.

http://abstract.rsna.org/uploads/2014/14015122/14015122_r9sr.pdf

Tavri, S, Ghasemi-rad, M, Sheth, R, Hesketh, R, Uygun, B, Usta, B, Kong, D, Oklu, R, IR Targeted Liver Decellularization and Cell Therapy: Fantasy or Reality to Improve Liver Function?.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14015122.html