Neuroblastoma is the third commonest childhood tumour after leukaemia and brain malignancies. I-123-labelled MIBG scintigraphy is considered the best diagnostic technique for evaluation of disease activity at presentation and at follow-up with a reported sensitivity of 93% and specificity of almost 100%. Interpretation of CT and MRI after surgery or radiotherapy can be challenging but integration with MIBG SPECT enables a direct correlation of anatomic information and functional information resulting in better localization and definition of scintigraphic findings.
Objectives of this pictorial review:
To review the contribution of MIBG SPECT/CT in diagnosis of Neuroblastoma.
To illustrate the diagnostic usefulness of MIBG SPECT/CT in the assessment of Neuroblastoma post treatment including improved disease localization and identification of metastatic disease.
Outline:
MIBG SPECT/CT plays a useful role in the diagnosis and follow-up of Neuroblastoma. It improves image interpretation and therefore assists in future treatment planning.
This pictorial review includes cases demonstrating the benefits of MIBG SPECT/CT including:
Accurate anatomic localization of the pathologic site.
Detection of metastatic disease.
Differentiating postsurgical changes from recurrent disease.
Early detection of disease relapse.
Carney, O,
Biassoni, L,
Easty, M,
The Role of MIBG SPECT/CT in Neuroblastoma: A Pictorial Review. Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL.
http://archive.rsna.org/2014/14015113.html
