Ailbhe C. O' Neill MBBCh, Presenter: Nothing to Disclose

Sreeharsha Tirumani MBBS, MD, Abstract Co-Author: Nothing to Disclose

Bhanusupriya Somarouthu MD, Abstract Co-Author: Nothing to Disclose

Akshay Baheti MBBS, MD, Abstract Co-Author: Nothing to Disclose

Jyothi Priya Jagannathan MD, Abstract Co-Author: Nothing to Disclose

Nikhil H. Ramaiya MD, Abstract Co-Author: Nothing to Disclose

Atul Bhanudas Shinagare MD, Abstract Co-Author: Nothing to Disclose

1. Pathogenesis and advances in genetics: High-grade serous ovarian cancer originates in the fimbria and is associated with p53 mutations compared to low grade that is associated with BRAF or erb-B2 mutations. 2. 2014 FIGO staging update: Positive retroperitoneal nodes moved to IIIA and IVA defined as pleural effusion with positive cytology, among other changes. 3. Metastatic pattern: Peritoneum, lymph nodes and liver common; thoracic (pleura, lymph nodes) uncommon; rarely brain metastases 4. Treatment options: a. Surgical options: Neo-adjuvant, adjuvant, cytoreduction, second look laparotomy b. Conventional platinum-based agents- intravenous, intraperitoneal c. Newer options- Anti-angiogenic agents (bevacizumab, cediranib), PARP inhibitors (olaparib), anti-HER2 agents (trastuzumab, pertuzumab), anti CA125 agents (oregovomab) 5. Complications: a. Intraperitoneal chemotherapy- Intestinal obstruction b. Anti-angiogenic drugs- Thromboembolic complications, hemorrhage, pneumatosis and intestinal perforation. c. Anti-HER2 agents- LV dysfunction.

• Epidemiology, pathogenesis,advances in genetics • Overview of the updated FIGO ovarian cancer staging system • Prognostic factors • Metastatic patterns • Treatment options for primary, recurrent tumor • Treatment-related complications

http://abstract.rsna.org/uploads/2014/14015016/14015016_oory.pdf

O' Neill, A, Tirumani, S, Somarouthu, B, Baheti, A, Jagannathan, J, Ramaiya, N, Shinagare, A, Epithelial Ovarian Cancer — Recent Advances and Implications for the Radiologists.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14015016.html