Sidhartha Tavri MBBS, Presenter: Nothing to Disclose

Mohammad Ghasemi-rad MD, Abstract Co-Author: Nothing to Disclose

Rahul Anil Sheth MD, Abstract Co-Author: Nothing to Disclose

Richard L. Hesketh, Abstract Co-Author: Nothing to Disclose

Berk Usta PhD, Abstract Co-Author: Nothing to Disclose

David S. Kong PhD, Abstract Co-Author: Nothing to Disclose

Rahmi Oklu MD, PhD, Abstract Co-Author: Nothing to Disclose

i) to address the limitations of the current in vitro tools and animal models in the drug discovery process ii) to review recent advances in the microfluidics technology towards the development of the organ-on-a-chip platform. We will use liver-on-a-chip as the primary example. iii) to review the liver tumor-on-a-chip platform for testing anti-cancer drugs and interventions, highlighting relevance to interventional oncology.

1) Overview of the traditional drug discovery process, highlighting the current lack of predictive in vitro tools and animal models for translation from bench to bedside. 2) Organ-on-a-chip: describe advances in microfluidics and microfabrication platforms and development of 3D cell culture models to mimic in vivo human environment. 3) Discuss liver-on-a-chip devices to mimic healthy liver physiology, investigate liver diseases, and test the toxicity of potential therapeutic drugs. 4) Compare and contrast the complimentary role of tumor-on-a-chip technology in interventional oncology for biomarker discovery, chemotherapeutic sensitivity and specificity analysis, developing targeted therapy, and monitoring treatment. Novel microfluidic designs containing microscopic probes can enable the study of IRE, microwave, cryo- and RFA on tumor tissue on a chip in real-time video microscopy will be discussed.

http://abstract.rsna.org/uploads/2014/14014992/14014992_vsbr.pdf

Tavri, S, Ghasemi-rad, M, Sheth, R, Hesketh, R, Usta, B, Kong, D, Oklu, R, Liver-on-a-chip: Personalization in Interventional Oncology?.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14014992.html