Christin A. Tiegs-Heiden MD, Abstract Co-Author: Nothing to Disclose

Erica Leigh Martin-Macintosh MD, Presenter: Nothing to Disclose

Christopher Harker Hunt MD, Abstract Co-Author: Nothing to Disclose

Geoffrey Bates Johnson MD, PhD, Abstract Co-Author: Nothing to Disclose

Patrick James Peller MD, Abstract Co-Author: Speakers Bureau, General Electric Company

Tau proteins play a central role in the pathogenesis of numerous neurodegenerative disorders, including Alzheimer’s disease. Understanding the spectrum of Tau mediated disease on FDG PET/CT is critical for accurate interpretation of these brain studies. The purpose of this project is to: Review molecular structure and function of the microtubule associated protein tau Demonstrate imaging features of major tauopathies, including Alzheimer’s disease, Pick’s disease, progressive supranuclear palsy, and corticobasal degeneration Highlight key concepts by providing case examples and correlation with anatomic imaging  

I. Tau     -Molecular structure     -Microtubule function     -Phosphorylation and deposition II. Diseases showing coexistence of tau and amyloid pathologies     -Alzheimer’s disease     -Creutzfeldt-Jakob disease     -Dementia pugilistica     -Down’s syndrome III. Diseases without distinct amyloid pathology     -Frontotemporal dementia with parkinsonism linked to chromosome 17     -Pick’s disease     -Corticobasal degeneration     -Progressive supranuclear palsy IV. Direct tau imaging  

http://abstract.rsna.org/uploads/2014/14014877/14014877_wqfe.pdf

Tiegs-Heiden, C, Martin-Macintosh, E, Hunt, C, Johnson, G, Peller, P, Multimodality Imaging and Pathophysiology of Tauopathies.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14014877.html