Behroze Vachha MD, PhD, Presenter: Nothing to Disclose

Bradley R. Buchbinder MD, Abstract Co-Author: Nothing to Disclose

Mykol Larvie MD, PhD, Abstract Co-Author: Nothing to Disclose

Naoro Tanaka MD, PhD, Abstract Co-Author: Nothing to Disclose

Matthew Nicholas DeSalvo MD, PhD, Abstract Co-Author: Nothing to Disclose

Otto Rapalino MD, Abstract Co-Author: Nothing to Disclose

Steven Marshall Stufflebeam MD, Abstract Co-Author: Nothing to Disclose

Resting state functional connectivity MRI (rs-fcMRI) identifies networks of functionally connected brain regions based on temporal correlations in spontaneous low frequency fluctuations of resting-state BOLD signals. Several networks have been elucidated, including motor, language, visual, attention, executive, and default mode networks. rs-fcMRI provides a rapid, non-invasive, task-free method of presurgically mapping eloquent cortex in patients, and has advantages and disadvantages compared to task-based fMRI. The greatest impact is in patients who cannot tolerate traditional task-based fMRI (e.g. young children, patients with developmental delay/dementia, and patients requiring anesthesia).

We provide an overview of the underlying principles, highlight the role of rs-fcMRI in neurologic disorders, discuss technical and interpretative challenges, and suggest quantitative techniques to incorporate rs-fcMRI in routine clinical practice. We review our institutional results with rs-fcMRI of patients with neurologic pathology including medically refractory epilepsy, traumatic brain injury, brain tumors and Alzheimer’s disease. Representative cases depicting the application of rs-fcMRI in comparison to conventional task-based fMRI will be presented. Technical and interpretive challenges will be illustrated.

http://abstract.rsna.org/uploads/2014/14014866/14014866_e5bl.pdf

Vachha, B, Buchbinder, B, Larvie, M, Tanaka, N, DeSalvo, M, Rapalino, O, Stufflebeam, S, Resting State fMRI: Principles, Applications and Pitfalls.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14014866.html