Nour-Eldin Abdelrehim Nour-Eldin MD, MSc, Presenter: Nothing to Disclose

Ola Abdelmonem Hassan Ahmed, Abstract Co-Author: Nothing to Disclose

Moritz Albrecht MD, Abstract Co-Author: Nothing to Disclose

Nagy Naguib Naeem Naguib MD, MSc, Abstract Co-Author: Nothing to Disclose

Stefan Zangos MD, Abstract Co-Author: Nothing to Disclose

Boris Schulz MD, Abstract Co-Author: Nothing to Disclose

Thomas Josef Vogl MD, PhD, Abstract Co-Author: Nothing to Disclose

To retrospectively evaluate the MRI features and volumetric changes of Neuroblastoma following conservative therapy (wait and see protocol).  

This retrospective study was approved by the institutional review board; informed consent was waived. The study included 72 patients of suprarenal neuroblastoma of which 10patients undergone conservative therapy (wait and see protocol) at age of less than 6 months (6females and 4males) in the time period between January 1997 and January 2010. Initial tumor stage were Stage1:in 40%(4 out of 10),Stage2 in30%(3out of10) and Stage4S in 30%(3 out of 10).CE-MRI was performed at 3months interval. Mixed linear modeling and logistic regression were performed including correlation to tumor markers.  

Mean tumor size at diagnosis was 8.2 cm in diameter (range 4.5–12.5). Mean tumor volume 86.0378cc (range: 5.2-347.94, SD: 114.44).The median follow-up time was 16 months (range 7–30 months). Seventy percent of cases showed spontaneous regression with complete remission after a median time of 6.3months(range 5–18 months).Those cases with complete remission characterized by well defined margin and homogenous MRI enhancement and absence of tumor necrosis (p=0.02). Thirty percent showed residual tumor (incomplete remission) after 2 years follow up in which surgery was indicated. MRI features tumors with incomplete remission were: ill defined margin and heterogenous contrast enhancement. Neither of the cases were associated with deletion of chromosome 1(p36) nor amplificatrion of MYCN. Tumor markers were normal for all cases with complete remission.  

MRI margin definition and tumor enhancement pattern are important imaging parameters to predict low risk suprarenal Neuroblastoma response to conservative therapy.  

MRI margin definition and tumor enhancement pattern could be of important clinical value to predict low risk suprarenal Neuroblastoma response following wait and see protocol therapy.  

Nour-Eldin, N, Abdelmonem Hassan Ahmed, O, Albrecht, M, Naguib, N, Zangos, S, Schulz, B, Vogl, T, MRI Features and Volumetric Changes of Suprarenal Neuroblastoma Following (Wait and See) Protocol of Therapy.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14014726.html