Mohamed Abou El-Ghar MSc, MD, Presenter: Nothing to Disclose

Huda Refaie MD, Abstract Co-Author: Nothing to Disclose

KHALED ZAKY SHEIR MD, Abstract Co-Author: Nothing to Disclose

Abdallah Abdelhamid Abdelaziz MBBCh, Abstract Co-Author: Nothing to Disclose

Hashim Mohamed Farg MBBCh, Abstract Co-Author: Nothing to Disclose

Tarek A. El-Diasty MBBCh, MD, Abstract Co-Author: Nothing to Disclose

To evaluate the role of diffusion weighted (DW) MRI in prediction of bladder tumor response to chemo-radiotherapy.

the study included 38 patients with fifty bladder tumors under follow up during chemo-radiotherapy for bladder tumor. The patients were followed up to 4 years and the tumor response including changes in the size after the chemo-radiotherapy. All of our patients underwent MRI before and after management, the restricted diffusion and the ADC values were calculated at every study.  

Among our patients; the group treated with chemo-radiotherapy showed good response in 25 masses with tumor size reduction or resolution of the tumor, while in the other 25 masses there were no or increase in the tumor size with no statistical difference in the pretreatment ADC values between both groups but diffusion can detect the presence or absence of tumor after treatment with high sensitivity and specificity in comparison to cystoscopy. The range and[mean and standard deviations] of the ADC values (×10−6 mm2/sec) in the masses respond to chemo-radiotherapy were 102-1360 [549+ 436], and for the other group that not respond to the chemo-radiotherapy were 103-970[394+352], p=0.425. In the patients group who respond to chemo-radiotherapy there were significant decrease in the ADC value of the mass from the pretreatment values, its range and[mean and standard deviations] of the ADC values (×10−6 mm2/sec) were 111-1730 [1791 + 2579] and p=0.009.

The pretreatment DWI with ADC map can’t predict the response to chemo-radiotherapy but the can detect the residual lesions accurately also there is increase in the post-treatment ADC values in cases respond to chemo-radiotherapy in comparison to the pretreatment values.

bladder tumor is a common problem in egypt and we use a DWI as a fast study to predict tumor response to chemo-radiotherapy and to evaluate the the changes of ADC in case of tumor response to the chemo-radiotherapy

El-Ghar, M, Refaie, H, SHEIR, K, Abdelaziz, A, Farg, H, El-Diasty, T, Can Diffusion Weighted MRI including ADC Values Predict the Response of Bladder Tumor to the Chemo-radiotherapy?.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14014489.html