Johannes Budjan MD, Presenter: Nothing to Disclose

Melissa Ong MD, Abstract Co-Author: Nothing to Disclose

Philipp Riffel MD, Abstract Co-Author: Nothing to Disclose

John Nicholas Morelli MD, Abstract Co-Author: Nothing to Disclose

Henrik J. Michaely MD, Abstract Co-Author: Speakers Bureau, Siemens AG Speakers Bureau, Bayer AG Speakers Bureau, Guerbet SA

Stefan Oswald Schoenberg MD, PhD, Abstract Co-Author: Institutional research agreement, Siemens AG

Stefan Haneder MD, Abstract Co-Author: Nothing to Disclose

CAIPIRINHA-Dixon-TWIST (CDT)-VIBE is a robust method for abdominal magnetic resonance imaging providing both high spatial and high temporal resolution. The purpose of this study was to examine the influence of different gadolinium based contrast agents (GBCA) on image quality (IQ) with CDT-VIBE.

In this IRB-approved, retrospective, inter-individual comparison study, 86 patients scanned at 3T were included. Within 28 seconds, 14 high-resolution 3D datasets were acquired using CDT-VIBE. 37 patients received 0.1 mmol/kg gadoterate meglumine, 28 patients 0.1 mmol/kg gadobutrol, and 19 patients 0.1ml/kg gadoxetic acid. Two blinded, board-certified radiologists assessed the image quality on a 5 point scale (1, nondiagnostic; 5, excellent image quality), as well as the number of hepatic arterial dominant (HAD) phases.

Regardless of the used GBCA, CDT-VIBE provided good results in terms of best IQ achieved among all 14 datasets (gadobutrol 4.3, gadoterate meglumine 3.9, gadoxetic acid 3.7). With respect to worst IQ, the three groups showed statistically significant differences with gadobutrol receiving the highest (3.6), gadoxetic acid the lowest (2.4) rating. No statistically significant differences were found regarding the number of HAD phases.

Applying a CDT-VIBE technique, different classes of gadolinium-based contrast agents can be utilized for dynamic liver imaging with good image quality.

As CDT-VIBE provides good image quality regardless of the applied contrast agent, it can be beneficial in various imaging settings, e.g. by combining its high spatial and temporal resolution with advantages of hepatocyte specific contrast agents.

Budjan, J, Ong, M, Riffel, P, Morelli, J, Michaely, H, Schoenberg, S, Haneder, S, CAIPIRINHA-Dixon-TWIST (CDT)-volume-Interpolated Breath-hold Examination (VIBE) for Abdominal Imaging: Comparison of Gadoterate Meglumine, Gadobutrol and Gadoxetic Acid.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14014268.html