Ashlesha Satish Udare MBBS, MD, Presenter: Nothing to Disclose

Rashmi Rakesh Badhe, Abstract Co-Author: Nothing to Disclose

Bhawan Krishna Paunipagar MD, Abstract Co-Author: Nothing to Disclose

Satish Satish Gaitonde, Abstract Co-Author: Nothing to Disclose

Namita Kamath MD, MBBS, Abstract Co-Author: Nothing to Disclose

Ritesh Dholu MD, Abstract Co-Author: Nothing to Disclose

Shrinivas Balaji Desai MD, Abstract Co-Author: Nothing to Disclose

1. To present the International Autoimmune Hepatitis Group(IAIHG) classification of the Overlap syndromes 2. To understand its clinical, serological findings, histopathology and management 3. To elucidate the role of imaging in diagnosis, classification, prognosis and post-treatment follow-up of overlap syndromes      

Definition:Overlap syndromes are distinct entities on their own, with a variety of autoimmune manifestations presenting in a susceptible individual. Clinical manifestations &Serological findings: Circulating auto-antibodies: ANA,SMA, anti-LKM-1, anti-LC1, and pANCA Histopathological features: Interface hepatitis, Portal inflammation, Biliary changes, Granulomas Imaging features: PSC-type overlap syndrome  -Imaging features of PSC type:central macroregeneration, peripheral atrophy -US: Wall thickening, beading -MRCP features: biliary duct beading, biliary dilation, diverticula -Liver specific contrast excretion pattern PBC (Primary Biliary Cirrhosis) type -hypointensity surrounding the portal venous branches on T1-weighted and T2-weighted images in patients with PBC, termed the ‘‘periportal halo sign.’’  Evaluation of fibrosis with MR Elastography Screening for complications: IBD, cholangiocarcinoma and noncirrhotic portal hypertension Treatment & interventions

http://abstract.rsna.org/uploads/2014/14014252/14014252_nmtc.pdf

Udare, A, Badhe, R, Paunipagar, B, Gaitonde, S, Kamath, N, Dholu, R, Desai, S, Overlap Syndromes of Autoimmune Chronic Liver Disease: What the Radiologist Needs to Know.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14014252.html