Zhu Xiaomei, Abstract Co-Author: Nothing to Disclose

Felix Schwab PhD, Abstract Co-Author: Nothing to Disclose

Daniel Theisen MD, Abstract Co-Author: Nothing to Disclose

Mike Notohamiprodjo, Abstract Co-Author: Nothing to Disclose

Konstantin Nikolaou MD, Abstract Co-Author: Speakers Bureau, Siemens AG Speakers Bureau, Bracco Group Speakers Bureau, Bayer AG

Fabian Bamberg MD, MPH, Presenter: Speakers Bureau, Bayer AG Speakers Bureau, Siemens AG Research Grant, Bayer AG Research Grant, Siemens AG

To determine the feasibility of free-breathing, GRAPPA based, real-time (RT) cine 3T cardiac magnetic resonance imaging (MRI) for the assessment of left-ventricular function in a cohort of patients with various cardiac conditions as compared to conventional segmented cine imaging.

In this prospective cohort study, subjects with cardiac conditions underwent both two RT cine sequences (high resolution [Tres: 48.8 ms, voxel: 1.9×3.1×10 mm3, R=5] and low resolution [Tres: 51.3 ms, voxel: 2.5×5.0×10 mm3, R=3]) and standard segmented cine imaging (Tres: 31.8 ms, voxel: 1.6×1.6×10 mm3, R=2) using a 3T system. Standard qualitative and quantitative parameters of left-ventricular function, including end-diastolic and end-systolic volume (EDV and ESV), stroke volume, ejection fraction, myocardial mass (MM), and wall thickness were quantified by two independent, blinded investigators. Univariate and multivariate comparisons were performed in order to identify differences and associations with patient-related factors.

Among 25 subjects, 24 were included in the analysis (mean age: 50.5, 67% male, 25% with cardiomyopathy). For both RT cine sequences, agreement with the segmented cine imaging with respect to detection of regional wall motion abnormality was very good (κ=0.71 and κ=0.73 for high and low resolution; respectively). RT cine derived quantitative parameters of volumes and MM were strongly correlated with segmented cine imaging (ICC: >0.72 and ICC: >0.80 for high and low resolution RT cine; respectively) but correlation for peak ejection and filling rates were moderate to poor for high (ICC: 0.33 and 0.23; respectively) and low resolution RT cines (ICC: 0.40 and 0.33; respectively). Similarly, RT cines significantly underestimated peak ejection and filling rates (>103.2±178 ml/s) while observed differences were relatively low for volumes, MM and wall thickness when compared with segmented cines. Among patient factors, heart rate was strongly predictive for deviation of measurements (p<0.05).

Both RT cine sequences at 3T are feasible for qualitative and quantitative assessment of left ventricular function but results in significant underestimation of peak ejection and filling rates.

RT GRAPPA-based cine imaging at 3T can be used in clincial patients for assessment of left ventricular function but results in significant underestimation of peak ejection and filling rates.

Xiaomei, Z, Schwab, F, Theisen, D, Notohamiprodjo, M, Nikolaou, K, Bamberg, F, Feasibility of Free-Breathing, GRAPPA-Based, Real-Time Cardiac Cine Assessment of Left-ventricular Function in Cardiovascular Patients at 3T.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14014132.html