JING PENG MD, Presenter: Nothing to Disclose

Kuncheng Li MD, Abstract Co-Author: Nothing to Disclose

Peipeng Liang, Abstract Co-Author: Nothing to Disclose

Jiangtao Liu, Abstract Co-Author: Nothing to Disclose

xin ma, Abstract Co-Author: Nothing to Disclose

Gang Wang, Abstract Co-Author: Nothing to Disclose

yang li, Abstract Co-Author: Nothing to Disclose

Dysconnectivity hypothesis posits that major depressive disorder (MDD) relates to abnormal resting-state connectivity within the default-mode network (DMN).Posterior cingulate cortex (PCC) is believed to have a key role in DMN and be involved in the pathophysiology of MDD. The goal of this study is to investigate whole-brain functional connectivity of PCC during resting state in subjects with MDD.

A total of 17 patients with first-episode, drug-naive MDD patients and 30 healthy well-matched volunteers were prospectively examined. Resting-state brain functional connectivity analysis was used to examine the correlation between the PCC and whole-brain regions.

Compared with healthy controls, MDD patients showed significantly decreased functional connectivity of the PCC in the left middle temporal gyrus and right superior frontal gyrus. Increased functional connectivity of the PCC was detected in the right insula, right transverse temporal gyrus, left precuneus, right lingual gyrus, left posterior cingulate, left superior/middle frontal gyrus, right cuneus, and right precuneus.

Our findings suggested that abnormal functional connectivity of the DMN exist in first-episode, drug-naive MDD and further highlight the importance of the DMN in the pathophysiology of MDD.

Resting-state fMRI can demonstrate functional connectivity of the default mode network in MDD and further highlight the importance of the DMN in the pathophysiology of MDD.

PENG, J, Li, K, Liang, P, Liu, J, ma, x, Wang, G, li, y, Abnormal Functional Connectivity of the Default Mode Network in Firstt-episode, Drug-naïve Major Depressive Disorder: A Resting-state fMRI Study.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14013865.html