Xiaohong Ma, Presenter: Nothing to Disclose

Xinming Zhao, Abstract Co-Author: Nothing to Disclose

Han Ouyang MD, Abstract Co-Author: Nothing to Disclose

feng ye, Abstract Co-Author: Nothing to Disclose

chunwu zhou, Abstract Co-Author: Nothing to Disclose

To evaluate the value of apparent diffusion coefficient (ADC) histogram analysis, alpha-fetoprotein (AFP) and transferrin (TFN) for predicting tumor progressive in patients with hepatocellular carcinoma (HCC) treated with radiofrequency ablation (RFA)

In a retrospective study, both 33 progressive patients and 31 stable patients with biopsy-proven HCC underwent breath-hold diffusion-weighted imaging (DWI) (b=800 sec/mm2) on a 3.0T MR scanner before RFA treatment. The pre-treatment ADC value was averaged from the lowest to 10th, 30th, 50th, and 100th percentile of histogram respectively, called ADC10, ADC30, ADC50 and ADC100. The ratio of ADC10, ADC30, ADC50 and ADC100 to mean ADC of non-lesion area were calculated, named RADC10, RADC30, RADC50 and RADC100. All the ADC and RADC values, AFP, TFN, sex, age and maximal tumor diameter (MTD) were statistically analyzed.

The ADC30, ADC50、ADC100、RADC30, RADC50及RADC100 values of tumors in the progressive group were significantly higher than those of the stable group (P < 0.05, respectively). Univariate Cox regression analysis indicated that RADC10, RADC30, RADC50 values of the tumor were significantly associated with disease progressive survival (DPS) (RR = 31.02, 43.84 and 44.29; P < 0.05, respectively). In multivariate analysis, the RADC50 value of tumors was a significant predictor for tumor progressive (P = 0.04, χ2 = 4.12). When the cut-off value of RADC50 (0.71) was used, the DPS of above the cut-off value group was significantly lower than that of below the cut-off value group (χ2 = 5.12，P = 0.02).

Pre-RFA RADC values especially RADC50 value by the ADC histogram analysis may be a predictor for tumor progressive in patients with HCC treated with RFA. Pre-treatment level of AFP and TFN could not predict the prognosis of HCC before RFA treatment.

Pre-RFA ADC histogram analysis may serve as a biomarker for predicting tumor progressive in patients with HCC treated with RFA.

Ma, X, Zhao, X, Ouyang, H, ye, f, zhou, c, Predictive Value of Apparent Diffusion Coefficient Histogram, Alpha-fetoprotein and Transferrin in Evaluation of Hepatocellular Carcinoma’ Response to Radiofrequency Ablation.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14013837.html